Skip to main content

featured publications

Publications
  • Publication categories: Top publication

    The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation.

    Cell

    Authors: Rainer Knoll, Elisa T Helbig, Kilian Dahm, Olufemi Bolaji, Frederik Hamm, Oliver Dietrich, Martina van Uelft, Sophie Müller, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Lev Petrov, Benjamin Krämer, Michael Kraut, Paula Stubbemann, Charlotte Thibeault, Sophia Brumhard, Heidi Theis, Gudrun Hack, Elena De Domenico, Jacob Nattermann, Matthias Becker, Marc D Beyer, David Hillus, Philipp Georg, Constantin Loers, Janina Tiedemann, Pinkus Tober-Lau, Lena Lippert, Belén Millet Pascual-Leone, Frank Tacke, Gernot Rohde, Norbert Suttorp, Martin Witzenrath, Antoine-Emmanuel Saliba, Thomas Ulas, Julia K Polansky, Birgit Sawitzki, Leif E Sander, Joachim L Schultze, Anna C Aschenbrenner, Florian Kurth

    View this publication
  • Publication categories: Top publication

    An amortized approach to non-linear mixed-effects modeling based on neural posterior estimation

    Proceedings of Machine Learning Research

    Authors: Jonas Arruda, Yannik Schälte, Clemens Peiter, Olga Teplytska, Ulrich Jaehde, Jan Hasenauer

    View this publication
  • Publication categories: Top publication

    Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS.

    Nature medicine

    Authors: Madhurima Chatterjee, Selcuk Özdemir, Christian Fritz, Wiebke Möbius, Luca Kleineidam, Eckhard Mandelkow, Jacek Biernat, Cem Doğdu, Oliver Peters, Nicoleta Carmen Cosma, Xiao Wang, Luisa-Sophia Schneider, Josef Priller, Eike Spruth, Andrea A Kühn, Patricia Krause, Thomas Klockgether, Ina R Vogt, Okka Kimmich, Annika Spottke, Daniel C Hoffmann, Klaus Fliessbach, Carolin Miklitz, Cornelia McCormick, Patrick Weydt, Björn Falkenburger, Moritz Brandt, René Guenther, Elisabeth Dinter, Jens Wiltfang, Niels Hansen, Mathias Bähr, Inga Zerr, Agnes Flöel, Peter J Nestor, Emrah Düzel, Wenzel Glanz, Enise Incesoy, Katharina Bürger, Daniel Janowitz, Robert Perneczky, Boris S Rauchmann, Franziska Hopfner, Olivia Wagemann, Johannes Levin, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Johannes Prudlo, Thomas Gasser, Kathrin Brockmann, David Mengel, Milan Zimmermann, Matthis Synofzik, Carlo Wilke, Judit Selma-González, Janina Turon-Sans, Miguel Angel Santos-Santos, Daniel Alcolea, Sara Rubio-Guerra, Juan Fortea, Álvaro Carbayo, Alberto Lleó, Ricardo Rojas-García, Ignacio Illán-Gala, Michael Wagner, Ingo Frommann, Sandra Roeske, Lucas Bertram, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Matthias Schmid, Rudi Beschorner, Annett Halle, Jochen Herms, Manuela Neumann, Nicolas R Barthélemy, Randall J Bateman, Patrizia Rizzu, Peter Heutink, Oriol Dols-Icardo, Günter Höglinger, Andreas Hermann, Anja Schneider

    View this publication
  • Publication categories: Top publication

    Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

    Nature Immunology

    Authors: H. Theobald, D. A. Bejarano, N. Katzmarski, J. Haub, J. Schulte-Schrepping, J. Yu, K. Bassler, A. L. Ament, C. Osei-Sarpong, F. Piattini, L. Vornholz, W. T’Jonck, A. H. Györfi, H. Hayer, X. Yu, S. Sheoran, A. Al Jawazneh, S. Chakarov, K. Haendler, G. D. Brown, D. L. Williams, L. Bosurgi, J. H. W. Distler, F. Ginhoux, J. Ruland, M. D. Beyer, M. Greter, C. C. Bain, A. I. Vazquez-Armendariz, M. Kopf, J. L. Schultze & A. Schlitzer

    View this publication
  • Publication categories: Top publication

    TGF-β specifies T versus T17 cell fates in murine CD4 T cells through c-Maf.

    Science immunology

    Authors: Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefan Krebs, Helmut Blum, Zeinab Abdullah, Katrin Paeschke, Caspar Ohnmacht, Christian Neumann, Adrian Liston, Felix Meissner, Thomas Korn, Jan Hasenauer, Vigo Heissmeyer, Marc Beyer, Axel Kallies, Lukas T Jeker, Dirk Baumjohann

    View this publication
  • Publication categories: Top publication

    Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.

    Science (New York, N.Y.)

    Authors: Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja Vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H Christensen, Yonas M Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E Müller, Manabu Igarashi, Hiroki Kato

    View this publication
  • Publication categories: Top publication

    Antiviral signalling by a cyclic nucleotide activated CRISPR protease.

    Nature

    Authors: Christophe Rouillon, Niels Schneberger, Haotian Chi, Katja Blumenstock, Stefano Da Vela, Katrin Ackermann, Jonas Moecking, Martin F Peter, Wolfgang Boenigk, Reinhard Seifert, Bela E Bode, Jonathan L Schmid-Burgk, Dmitri Svergun, Matthias Geyer, Malcolm F White, Gregor Hagelueken

    View this publication
  • Publication categories: Top publication

    Mitochondrial damage activates the NLRP10 inflammasome.

    Nature immunology

    Authors: Tomasz Próchnicki, Matilde B Vasconcelos, Kim S Robinson, Matthew S J Mangan, Dennis De Graaf, Kateryna Shkarina, Marta Lovotti, Lena Standke, Romina Kaiser, Rainer Stahl, Fraser G Duthie, Maximilian Rothe, Kateryna Antonova, Lea-Marie Jenster, Zhi Heng Lau, Sarah Rösing, Nora Mirza, Clarissa Gottschild, Dagmar Wachten, Claudia Günther, Thomas A Kufer, Florian I Schmidt, Franklin L Zhong, Eicke Latz

    View this publication
  • Publication categories: Top publication

    Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury.

    Journal of hepatology

    Authors: Carl-Philipp Hackstein, Jasper Spitzer, Konstantinos Symeonidis, Helena Horvatic, Tanja Bedke, Babett Steglich, Sabine Klein, Lisa M Assmus, Alexandru Odainic, Jennifer Szlapa, Nina Kessler, Marc Beyer, Ricarda Schmithausen, Eicke Latz, Richard A Flavell, Natalio Garbi, Christian Kurts, Beate M Kümmerer, Jonel Trebicka, Axel Roers, Samuel Huber, Susanne V Schmidt, Percy A Knolle, Zeinab Abdullah

    View this publication
  • Publication categories: Top publication

    Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19.

    Nature

    Authors: Fotios Karagiannis, Konrad Peukert, Laura Surace, Marcel Michla, Fabian Nikolka, Mario Fox, Patricia Weiss, Caroline Feuerborn, Paul Maier, Susanne Schulz, Burcu Al, Benjamin Seeliger, Tobias Welte, Sascha David, Inge Grondman, Aline H de Nooijer, Peter Pickkers, Jan Lukas Kleiner, Marc Moritz Berger, Thorsten Brenner, Christian Putensen, Hiroki Kato, Natalio Garbi, Mihai G Netea, Karsten Hiller, Katarzyna Placek, Christian Bode, Christoph Wilhelm

    View this publication
  • Publication categories: Top publication

    Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.

    Nature

    Authors: Inga V Hochheiser, Michael Pilsl, Gregor Hagelueken, Jonas Moecking, Michael Marleaux, Rebecca Brinkschulte, Eicke Latz, Christoph Engel, Matthias Geyer

    View this publication
  • Publication categories: Top publication

    Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.

    Cell

    Authors: Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T Heneka

    View this publication
  • Publication categories: Top publication

    LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.

    Nature biotechnology

    Authors: Kerstin U Ludwig, Ricarda M Schmithausen, David Li, Max L Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikołaj Słabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas S Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara M Hochfeld, Eva C Beins, Ines H Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Eva-Maria C Moench, Jacob D Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon Macrae, Markus M Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang, Jonathan L Schmid-Burgk

    View this publication
  • Publication categories: Top publication

    Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

    Immunity

    Authors: Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J Rieke, Jenny Bischoff, Malte B Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D Nischalke, Christian P Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne V Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J Ball, Joe M Johnson, Paul-Albert Koenig, Florian I Schmidt, Muzlifah Haniffa, James R Heath, Beate M Kümmerer, Verena Keitel, Björn Jensen, Paula Stubbemann, Florian Kurth, Leif E Sander, Birgit Sawitzki, Anna C Aschenbrenner, Joachim L Schultze, Jacob Nattermann

    View this publication
  • Publication categories: Top publication

    Transmission of trained immunity and heterologous resistance to infections across generations.

    Nature immunology

    Authors: Natalie Katzmarski, Jorge Domínguez-Andrés, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Händler, Heidi Theis, Marc Beyer, Jos W M van der Meer, Leo A B Joosten, Jörn Walter, Joachim L Schultze, Thierry Roger, Evangelos J Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G Netea

    View this publication
  • Publication categories: Top publication

    Swarm Learning for decentralized and confidential clinical machine learning.

    Nature

    Authors: Stefanie Warnat-Herresthal, Hartmut Schultze, Krishnaprasad Lingadahalli Shastry, Sathyanarayanan Manamohan, Saikat Mukherjee, Vishesh Garg, Ravi Sarveswara, Kristian Händler, Peter Pickkers, N Ahmad Aziz, Sofia Ktena, Florian Tran, Michael Bitzer, Stephan Ossowski, Nicolas Casadei, Christian Herr, Daniel Petersheim, Uta Behrends, Fabian Kern, Tobias Fehlmann, Philipp Schommers, Clara Lehmann, Max Augustin, Jan Rybniker, Janine Altmüller, Neha Mishra, Joana P Bernardes, Benjamin Krämer, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Elena De Domenico, Christian Siever, Michael Kraut, Milind Desai, Bruno Monnet, Maria Saridaki, Charles Martin Siegel, Anna Drews, Melanie Nuesch-Germano, Heidi Theis, Jan Heyckendorf, Stefan Schreiber, Sarah Kim-Hellmuth, Jacob Nattermann, Dirk Skowasch, Ingo Kurth, Andreas Keller, Robert Bals, Peter Nürnberg, Olaf Rieß, Philip Rosenstiel, Mihai G Netea, Fabian Theis, Sach Mukherjee, Michael Backes, Anna C Aschenbrenner, Thomas Ulas, Monique M B Breteler, Evangelos J Giamarellos-Bourboulis, Matthijs Kox, Matthias Becker, Sorin Cheran, Michael S Woodacre, Eng Lim Goh, Joachim L Schultze

    View this publication
  • Publication categories: Top publication

    Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.

    Immunity

    Authors: Thomas Ostendorf, Thomas Zillinger, Katarzyna Andryka, Thais Marina Schlee-Guimaraes, Saskia Schmitz, Samira Marx, Kübra Bayrak, Rebecca Linke, Sarah Salgert, Julia Wegner, Tatjana Grasser, Sonja Bauersachs, Leon Soltesz, Marc P Hübner, Maximilian Nastaly, Christoph Coch, Matthias Kettwig, Ingo Roehl, Marco Henneke, Achim Hoerauf, Winfried Barchet, Jutta Gärtner, Martin Schlee, Gunther Hartmann, Eva Bartok

    View this publication
  • Publication categories: Top publication

    Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation.

    Immunity

    Authors: Fotios Karagiannis, Schekufe Kharabi Masouleh, Klaus Wunderling, Jayagopi Surendar, Vanessa Schmitt, Alexander Kazakov, Marcel Michla, Michael Hölzel, Christoph Thiele, Christoph Wilhelm

    View this publication
  • Publication categories: Top publication

    A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation.

    Science translational medicine

    Authors: Katarzyna Jobin, Natascha E Stumpf, Sebastian Schwab, Melanie Eichler, Patrick Neubert, Manfred Rauh, Marek Adamowski, Olena Babyak, Daniel Hinze, Sugirthan Sivalingam, Christina Weisheit, Katharina Hochheiser, Susanne V Schmidt, Mirjam Meissner, Natalio Garbi, Zeinab Abdullah, Ulrich Wenzel, Michael Hölzel, Jonathan Jantsch, Christian Kurts

    View this publication
  • Publication categories: Top publication

    Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma.

    Immunity

    Authors: Maike Effern, Nicole Glodde, Matthias Braun, Jana Liebing, Helena N Boll, Michelle Yong, Emma Bawden, Daniel Hinze, Debby van den Boorn-Konijnenberg, Mila Daoud, Pia Aymans, Jennifer Landsberg, Mark J Smyth, Lukas Flatz, Thomas Tüting, Tobias Bald, Thomas Gebhardt, Michael Hölzel

    View this publication
  • Publication categories: Top publication

    BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination.

    Nature communications

    Authors: Krista E van Meijgaarden, Wenchao Li, Simone J C F M Moorlag, Valerie A C M Koeken, Hans J P M Koenen, Leo A B Joosten, Annapurna Vyakarnam, Asma Ahmed, Srabanti Rakshit, Vasista Adiga, Tom H M Ottenhoff, Yang Li, Mihai G Netea, Simone A Joosten

    View this publication
  • Publication categories: Top publication

    CRELD1 modulates homeostasis of the immune system in mice and humans.

    Nature immunology

    Authors: Lorenzo Bonaguro, Maren Köhne, Lisa Schmidleithner, Jonas Schulte-Schrepping, Stefanie Warnat-Herresthal, Arik Horne, Paul Kern, Patrick Günther, Rob Ter Horst, Martin Jaeger, Souad Rahmouni, Michel Georges, Christine S Falk, Yang Li, Elvira Mass, Marc Beyer, Leo A B Joosten, Mihai G Netea, Thomas Ulas, Joachim L Schultze, Anna C Aschenbrenner

    View this publication
  • Publication categories: Top publication

    Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

    Immunity

    Authors: Lisa Schmidleithner, Yasser Thabet, Eva Schönfeld, Maren Köhne, Daniel Sommer, Zeinab Abdullah, Timothy Sadlon, Collins Osei-Sarpong, Kotha Subbaramaiah, Francesca Copperi, Kristian Haendler, Tamas Varga, Oliver Schanz, Svenja Bourry, Kevin Bassler, Wolfgang Krebs, Annika E Peters, Ann-Kathrin Baumgart, Maria Schneeweiss, Kathrin Klee, Susanne V Schmidt, Simone Nüssing, Jil Sander, Naganari Ohkura, Andreas Waha, Tim Sparwasser, F Thomas Wunderlich, Irmgard Förster, Thomas Ulas, Heike Weighardt, Shimon Sakaguchi, Alexander Pfeifer, Matthias Blüher, Andrew J Dannenberg, Nerea Ferreirós, Louis J Muglia, Claudia Wickenhauser, Simon C Barry, Joachim L Schultze, Marc Beyer

    View this publication
  • Publication categories: Top publication

    NLRP3 inflammasome activation drives tau pathology.

    Nature

    Authors: Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M McManus, Dario Tejera, Angelika Griep, Francesco Santarelli, Frederic Brosseron, Sabine Opitz, James Stunden, Maximilian Merten, Rakez Kayed, Douglas T Golenbock, David Blum, Eicke Latz, Luc Buée, Michael T Heneka

    View this publication
  • Publication categories: Top publication

    Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.

    Neuron

    Authors: José Ricardo Vieira, Bhavin Shah, Sebastian Dupraz, Isidora Paredes, Patricia Himmels, Géza Schermann, Heike Adler, Alessia Motta, Lea Gärtner, Ariadna Navarro-Aragall, Elena Ioannou, Elena Dyukova, Remy Bonnavion, Andreas Fischer, Dario Bonanomi, Frank Bradke, Christiana Ruhrberg, Carmen Ruiz de Almodóvar

    View this publication
  • Publication categories: Top publication

    A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.

    Nucleic acids research

    Authors: Ann Kristin de Regt, Kanchan Anand, Katrin Ciupka, Felix Bender, Karl Gatterdam, Bastian Putschli, David Fusshöller, Daniel Hilbig, Alexander Kirchhoff, Charlotte Hunkler, Steven Wolter, Agathe Grünewald, Christina Wallerath, Christine Schuberth-Wagner, Janos Ludwig, Katrin Paeschke, Eva Bartok, Gregor Hagelueken, Gunther Hartmann, Thomas Zillinger, Matthias Geyer, Martin Schlee

    View this publication
  • Publication categories: Top publication

    Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release.

    Nature communications

    Authors: Sarah Rösing, Fabian Ullrich, Susann Meisterfeld, Franziska Schmidt, Laura Mlitzko, Marijana Croon, Ryan G Nattrass, Nadia Eberl, Julia Mahlberg, Martin Schlee, Anja Wieland, Philipp Simon, Daniel Hilbig, Ulrike Reuner, Alexander Rapp, Julia Bremser, Peter Mirtschink, Stephan Drukewitz, Thomas Zillinger, Stefan Beissert, Katrin Paeschke, Gunther Hartmann, Aleksandra Trifunovic, Eva Bartok, Claudia Günther

    View this publication
  • Publication categories: Top publication

    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.

    The Journal of experimental medicine

    Authors: Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D Wuerth, Lisa D J Schiffelers, Yonas M Tesfamariam, Florian N Gohr, Laura Klein, Ines H Kaltheuner, Stefan Ebner, Dorothee J Lapp, Jacob Mayer, Jonas Moecking, Hidde L Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M Kümmerer, Florian I Schmidt

    View this publication
  • Publication categories: Top publication

    DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions.

    Nature communications

    Authors: Markus Sauer, Stefan A Juranek, James Marks, Alessio De Magis, Hinke G Kazemier, Daniel Hilbig, Daniel Benhalevy, Xiantao Wang, Markus Hafner, Katrin Paeschke

    View this publication
  • Publication categories: Top publication

    UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence.

    Nature communications

    Authors: Alessio De Magis, Michaela Limmer, Venkat Mudiyam, David Monchaud, Stefan Juranek, Katrin Paeschke

    View this publication
  • Publication categories: Top publication

    Fate mapping reveals compartment-specific clonal expansion of mononuclear phagocytes during kidney disease.

    Kidney international

    Authors: Junping Yin, Qi Mei, Marco Prinz, Zeinab Abdullah, Ulf Panzer, Jian Li, Sibylle von Vietinghoff, Christian Kurts

    View this publication
  • Publication categories: Top publication

    Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.

    The Journal of experimental medicine

    Authors: Nina Kessler, Susanne F Viehmann, Calvin Krollmann, Karola Mai, Katharina M Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M C Böhner, Dennis Huugen, Carina C de Oliveira Mann, Simon Otten, Stefanie A I Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A Lyons, Peter Boor, Angela Rösen-Wolff, Lino L Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi

    View this publication
  • Publication categories: Top publication

    Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany.

    Nature communications

    Authors: N Ahmad Aziz, Victor M Corman, Antje K C Echterhoff, Marcel A Müller, Anja Richter, Antonio Schmandke, Marie Luisa Schmidt, Thomas H Schmidt, Folgerdiena M de Vries, Christian Drosten, Monique M B Breteler

    View this publication
  • Publication categories: Top publication

    From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists.

    Scientific data

    Authors: Lea Seep, Stephan Grein, Iva Splichalova, Danli Ran, Mickel Mikhael, Staffan Hildebrand, Mario Lauterbach, Karsten Hiller, Dalila Juliana Silva Ribeiro, Katharina Sieckmann, Ronja Kardinal, Hao Huang, Jiangyan Yu, Sebastian Kallabis, Janina Behrens, Andreas Till, Viktoriya Peeva, Akim Strohmeyer, Johanna Bruder, Tobias Blum, Ana Soriano-Arroquia, Dominik Tischer, Katharina Kuellmer, Yuanfang Li, Marc Beyer, Anne-Kathrin Gellner, Tobias Fromme, Henning Wackerhage, Martin Klingenspor, Wiebke K Fenske, Ludger Scheja, Felix Meissner, Andreas Schlitzer, Elvira Mass, Dagmar Wachten, Eicke Latz, Alexander Pfeifer, Jan Hasenauer

    View this publication
  • Publication categories: Top publication

    A protocol for dynamic model calibration.

    Briefings in bioinformatics

    Authors: Alejandro F Villaverde, Dilan Pathirana, Fabian Fröhlich, Jan Hasenauer, Julio R Banga

    View this publication
  • Publication categories: Top publication

    Mini-batch optimization enables training of ODE models on large-scale datasets.

    Nature communications

    Authors: Paul Stapor, Leonard Schmiester, Christoph Wierling, Simon Merkt, Dilan Pathirana, Bodo M H Lange, Daniel Weindl, Jan Hasenauer

    View this publication
  • Publication categories: Top publication

    Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells.

    Frontiers in immunology

    Authors: Philipp Burt, Michael Peine, Caroline Peine, Zuzanna Borek, Sebastian Serve, Michael Floßdorf, Ahmed N Hegazy, Thomas Höfer, Max Löhning, Kevin Thurley

    View this publication
  • Publication categories: Top publication

    Distribution modeling quantifies collective T cell decision circuits in chronic inflammation.

    Science advances

    Authors: Philipp Burt, Kevin Thurley

    View this publication
  • Publication categories: Top publication

    Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke.

    Nature neuroscience

    Authors: Yves Werner, Elvira Mass, Praveen Ashok Kumar, Thomas Ulas, Kristian Händler, Arik Horne, Kathrin Klee, Amelie Lupp, Dagmar Schütz, Friederike Saaber, Christoph Redecker, Joachim L Schultze, Frederic Geissmann, Ralf Stumm

    View this publication
  • Publication categories: Top publication

    Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.

    Cell reports

    Authors: Theodore S Kapellos, Kevin Baßler, Wataru Fujii, Christina Nalkurthi, Anna C Schaar, Lorenzo Bonaguro, Tal Pecht, Izabela Galvao, Shobhit Agrawal, Adem Saglam, Erica Dudkin, Amit Frishberg, Elena de Domenico, Arik Horne, Chantal Donovan, Richard Y Kim, David Gallego-Ortega, Tessa E Gillett, Meshal Ansari, Jonas Schulte-Schrepping, Nina Offermann, Ignazio Antignano, Burcu Sivri, Wenying Lu, Mathew S Eapen, Martina van Uelft, Collins Osei-Sarpong, Maarten van den Berge, Hylke C Donker, Harry J M Groen, Sukhwinder S Sohal, Johanna Klein, Tina Schreiber, Andreas Feißt, Ali Önder Yildirim, Herbert B Schiller, Martijn C Nawijn, Matthias Becker, Kristian Händler, Marc Beyer, Melania Capasso, Thomas Ulas, Jan Hasenauer, Carmen Pizarro, Fabian J Theis, Philip M Hansbro, Dirk Skowasch, Joachim L Schultze

    View this publication
  • Publication categories: Top publication

    Long-term monitoring of SARS-CoV-2 seroprevalence and variants in Ethiopia provides prediction for immunity and cross-immunity.

    Nature communications

    Authors: Simon Merkt, Solomon Ali, Esayas Kebede Gudina, Wondimagegn Adissu, Addisu Gize, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Kira Elsbernd, Rebecca Kisch, Sisay Sirgu Betizazu, Bereket Fantahun, Delayehu Bekele, Raquel Rubio-Acero, Mulatu Gashaw, Eyob Girma, Daniel Yilma, Ahmed Zeynudin, Ivana Paunovic, Michael Hoelscher, Helmut Blum, Jan Hasenauer, Arne Kroidl, Andreas Wieser

    View this publication
  • Publication categories: Top publication

    Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.

    Immunity

    Authors: Joana P Bernardes, Neha Mishra, Florian Tran, Thomas Bahmer, Lena Best, Johanna I Blase, Dora Bordoni, Jeanette Franzenburg, Ulf Geisen, Jonathan Josephs-Spaulding, Philipp Köhler, Axel Künstner, Elisa Rosati, Anna C Aschenbrenner, Petra Bacher, Nathan Baran, Teide Boysen, Burkhard Brandt, Niklas Bruse, Jonathan Dörr, Andreas Dräger, Gunnar Elke, David Ellinghaus, Julia Fischer, Michael Forster, Andre Franke, Sören Franzenburg, Norbert Frey, Anette Friedrichs, Janina Fuß, Andreas Glück, Jacob Hamm, Finn Hinrichsen, Marc P Hoeppner, Simon Imm, Ralf Junker, Sina Kaiser, Ying H Kan, Rainer Knoll, Christoph Lange, Georg Laue, Clemens Lier, Matthias Lindner, Georgios Marinos, Robert Markewitz, Jacob Nattermann, Rainer Noth, Peter Pickkers, Klaus F Rabe, Alina Renz, Christoph Röcken, Jan Rupp, Annika Schaffarzyk, Alexander Scheffold, Jonas Schulte-Schrepping, Domagoj Schunk, Dirk Skowasch, Thomas Ulas, Klaus-Peter Wandinger, Michael Wittig, Johannes Zimmermann, Hauke Busch, Bimba F Hoyer, Christoph Kaleta, Jan Heyckendorf, Matthijs Kox, Jan Rybniker, Stefan Schreiber, Joachim L Schultze, Philip Rosenstiel

    View this publication
  • Publication categories: Top publication

    GestaltMatcher facilitates rare disease matching using facial phenotype descriptors.

    Nature genetics

    Authors: Tzung-Chien Hsieh, Aviram Bar-Haim, Shahida Moosa, Nadja Ehmke, Karen W Gripp, Jean Tori Pantel, Magdalena Danyel, Martin Atta Mensah, Denise Horn, Stanislav Rosnev, Nicole Fleischer, Guilherme Bonini, Alexander Hustinx, Alexander Schmid, Alexej Knaus, Behnam Javanmardi, Hannah Klinkhammer, Hellen Lesmann, Sugirthan Sivalingam, Tom Kamphans, Wolfgang Meiswinkel, Frédéric Ebstein, Elke Krüger, Sébastien Küry, Stéphane Bézieau, Axel Schmidt, Sophia Peters, Hartmut Engels, Elisabeth Mangold, Martina Kreiß, Kirsten Cremer, Claudia Perne, Regina C Betz, Tim Bender, Kathrin Grundmann-Hauser, Tobias B Haack, Matias Wagner, Theresa Brunet, Heidi Beate Bentzen, Luisa Averdunk, Kimberly Christine Coetzer, Gholson J Lyon, Malte Spielmann, Christian P Schaaf, Stefan Mundlos, Markus M Nöthen, Peter M Krawitz

    View this publication
  • Publication categories: Top publication

    Assessment of the Genetic Spectrum of Uncombable Hair Syndrome in a Cohort of 107 Individuals.

    JAMA dermatology

    Authors: F Buket Basmanav, Nicole Cesarato, Sheetal Kumar, Oleg Borisov, Pavlos Kokordelis, Damian J Ralser, Maria Wehner, Daisy Axt, Xing Xiong, Holger Thiele, Vadim Dolgin, Yasmina Gossmann, Nadine Fricker, Malin Katharina Dewenter, Karsten Weller, Mohnish Suri, Herbert Reichenbach, Vinzenz Oji, Marie-Claude Addor, Karla Ramirez, Helen Stewart, Natalie Garcia Bartels, Lisa Weibel, Nicola Wagner, Susannah George, Arzu Kilic, Iliana Tantcheva-Poor, Alison Stewart, Nicola Dikow, Bettina Blaumeiser, Márta Medvecz, Ulrike Blume-Peytavi, Paul Farrant, Ramon Grimalt, Sara Bertok, Lisa Bradley, Marina Eskin-Schwartz, Ohad Samuel Birk, Anette Bygum, Michel Simon, Peter Krawitz, Christine Fischer, Henning Hamm, Günter Fritz, Regina C Betz

    View this publication
  • Publication categories: Top publication

    Identification of a founder mutation in KRT14 associated with Naegeli–Franceschetti–Jadassohn syndrome

    British Journal of Dermatology

    Authors: Ralser DJ, Kumar S, et int., Betz RC

    View this publication
  • Publication categories: Top publication

    Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by a 3D fast-marching algorithm.

    Kidney international

    Authors: Alexander M C Böhner, Alexander Effland, Alice M Jacob, Karin A M Böhner, Zeinab Abdullah, Sebastian Brähler, Ulrike I Attenberger, Martin Rumpf, Christian Kurts

    View this publication
  • Publication categories: Top publication

    Bayesian Uncertainty Estimation of Learned Variational MRI Reconstruction

    IEEE transactions on medical imaging

    Authors: Narnhofer D, Effland A, et int., Pock T

    View this publication
  • Publication categories: Top publication

    The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.

    Nucleic acids research

    Authors: Lucia A Torres-Fernández, Bettina Jux, Maximilian Bille, Yasmine Port, Karin Schneider, Matthias Geyer, Günter Mayer, Waldemar Kolanus

    View this publication
  • Publication categories: Top publication

    Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses.

    Nature communications

    Authors: Hongkui Xiao, Isabel Ulmert, Luisa Bach, Johanna Huber, Hamsa Narasimhan, Ilia Kurochkin, Yinshui Chang, Signe Holst, Urs Mörbe, Lili Zhang, Andreas Schlitzer, Carlos-Filipe Pereira, Barbara U Schraml, Dirk Baumjohann, Katharina Lahl

    View this publication
  • Publication categories: Top publication

    Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.

    Nature immunology

    Authors: Godfrey S Temba, Vesla Kullaya, Tal Pecht, Blandina T Mmbaga, Anna C Aschenbrenner, Thomas Ulas, Gibson Kibiki, Furaha Lyamuya, Collins K Boahen, Vinod Kumar, Leo A B Joosten, Joachim L Schultze, Andre J van der Ven, Mihai G Netea, Quirijn de Mast

    View this publication
  • Publication categories: Top publication

    Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.

    Nature communications

    Authors: Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D J Schiffelers, Florian I Schmidt, Matthias Geyer

    View this publication
  • Publication categories: Top publication

    Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs.

    The Journal of clinical investigation

    Authors: Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A Schildberg, Paul A Gleeson, Birgit M Reipert, Johannes Oldenburg, Christian Kurts

    View this publication
  • Publication categories: Top publication

    Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation.

    Nature communications

    Authors: Jonathan J Swietlik, Stefanie Bärthel, Chiara Falcomatà, Diana Fink, Ankit Sinha, Jingyuan Cheng, Stefan Ebner, Peter Landgraf, Daniela C Dieterich, Henrik Daub, Dieter Saur, Felix Meissner

    View this publication