Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes.
Neuron
View this publicationInstitute of Clinical Chemistry and Clinical Pharmacology
Our research aims to improve our understanding of the molecular and cellular mechanisms by which neuroinflammation affects immune cell function and the progression of neurodegenerative diseases. Specifically, we are interested in understanding the functions of microglia during health and disease, and how changes in their homeostasis may affect neuronal health and cell survival. To achieve this, we are using state-of-the-art techniques such as super-resolution microscopy, transcriptomic analysis and proteomics in a variety of cell culture settings. Our ultimate goal is to identify novel mechanisms causing microglial dysfunction and neurodegeneration, and to define preventative measures aimed at microglia.