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Dr. Matthias Becker

Member

German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1, 53127 Bonn

matthias.becker@dzne.de

+49 228 43302642

Our research focus is on development and application of generative AI. We use it to generate high quality synthetic cohort omics data for privacy-preserving data sharing in collaborations and demonstrate it in the classification of patients in Alzheimer’s diseases. Another development is DrugDiff, our diffusion model for the generation of novel small molecules with specific molecular properties. To make these approaches feasible, we use and investigate modular high-performance computing techniques.

Dr. Matthias Becker

Recent publications

  • Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth.

    Nature communications

    Authors: Greta Ehlers, Annika Marie Tödtmann, Lisa Holsten, Maike Willers, Julia Heckmann, Jennifer Schöning, Maximilian Richter, Anna Sophie Heinemann, Sabine Pirr, Alexander Heinz, Christian Dopfer, Kristian Händler, Matthias Becker, Johanna Büchel, Achim Wöckel, Constantin von Kaisenberg, Gesine Hansen, Karsten Hiller, Joachim L Schultze, Christoph Härtel, Wolfgang Kastenmüller, Martin Vaeth, Thomas Ulas, Dorothee Viemann

  • DrugDiff: small molecule diffusion model with flexible guidance towards molecular properties.

    Journal of cheminformatics

    Authors: Marie Oestreich, Erinc Merdivan, Michael Lee, Joachim L Schultze, Marie Piraud, Matthias Becker

All publications by Dr. Matthias Becker