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Jun. Prof. Dr. Niels Lemmermann

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Institute for Virology

University Hospital Bonn Venusberg-Campus 1, 53127 Bonn

lemmermann@uni-bonn.de

+49 228 28753445

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The host-specific cytomegaloviruses (CMV) are large DNA viruses of the beta herpesvirus family. After acute infection, CMV genomes remain in a state of replicative latency in host tissues for life, interrupted by episodes of transcriptional reactivation. The establishment of latency is the result of a long period of co-evolution between CMV and its host. During this time, the virus and host have developed a fine balance of immune evasion and immune control to maintain latency. Under conditions of immunosuppression, productive infection can occur by reactivation of the productive cycle of latent genomes. Primary infection or reactivation can lead to life-threatening diseases, e.g. interstitial pneumonia in immunocompromised patients after haematopoietic (stem) cell transplantation (HCT).

The main research topic of our group is to study the establishment of acute and latent CMV infection in a mouse model. We aim to understand the molecular and immunological basis of CMV control by the immune system and the viral countermeasures that lead to the establishment of latency.

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Recent publications

  • Dual fluorescence reporter mice for Ccl3 transcription, translation, and intercellular communication.

    The Journal of experimental medicine

    Authors: Maria Belen Rodrigo, Anna De Min, Selina Kathleen Jorch, Cristina Martin-Higueras, Ann-Kathrin Baumgart, Beata Goldyn, Sara Becker, Natalio Garbi, Niels A Lemmermann, Christian Kurts

  • Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development

    Blood

    Authors: Nadine Müller-Calleja, Kristin Grunz, T Son Nguyen, Jens Posma, Denise Pedrosa, Myriam Meineck, Anne Hollerbach, Johannes Braun, Sabine Muth, Hansjörg Schild, Kathrin Saar, Norbert Hübner, Sriram Krishnaswamy, Jennifer Royce, Luc Teyton, Niels Lemmermann, Julia Weinmann-Menke, Karl J Lackner, Wolfram Ruf

  • Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation.

    Frontiers in immunology

    Authors: Rafaela Holtappels, Julia K Büttner, Kirsten Freitag, Matthias J Reddehase, Niels A Lemmermann

All publications by Jun. Prof. Dr. Niels Lemmermann