Skip to main content

PD Dr. Beate Kümmerer

Member

Institute of Virology

Venusberg-Campus 1, 53127 Bonn

Beate.Kuemmerer@uni-bonn.de

+49 228 28714468

The research of our group is focused on viruses that are transmitted to humans by an insect vector (arthropod-borne viruses). We mainly work on orthoflaviviruses and alphaviruses. Using reverse genetic systems as major tools, we elucidate special functions of viral proteins in the viral life cycle. In addition, we perform antiviral compound testing against different arboviruses and are involved in vaccine studies focusing on the analyses of the adaptive immune response.
The group also deals with host cell antiviral proteins and examines virus-host interactions with the emphasis to analyze the interplay of the virus with the innate immune system, and to define determinants important for host range restriction. Analyses are performed both in vertebrate and insect cell systems as well as in living mosquitoes. For mosquitoes, we are especially interested to elucidate mechanisms involved in sensing of foreign RNA resulting in activation of the mosquito immune system.

PD Dr. Beate Kümmerer

Recent publications

  • 2'-O-methyltransferase-deficient yellow fever virus: Restricted replication in the midgut and secondary tissues of Aedes aegypti mosquitoes severely limits dissemination.

    PLoS pathogens

    Authors: Anja Vom Hemdt, Alexandra L Thienel, Katrin Ciupka, Janett Wieseler, Hannah M Proksch, Martin Schlee, Beate M Kümmerer

  • Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture.

    Nature communications

    Authors: Vasiliya Kril, Michael Hons, Celine Amadori, Claire Zimberger, Laurine Couture, Yara Bouery, Julien Burlaud-Gaillard, Andrei Karpov, Denis Ptchelkine, Alexandra L Thienel, Beate M Kümmerer, Ambroise Desfosses, Rhian Jones, Philippe Roingeard, Laurent Meertens, Ali Amara, Juan Reguera

  • Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control.

    Cell host & microbe

    Authors: Philipp Schult, Beate Mareike Kümmerer, Markus Hafner, Katrin Paeschke

All publications by PD Dr. Beate Kümmerer