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Prof. Dr. Dagmar Wachten

Member, Steering-Committee Member

Institute of Innate Immunity

Venusberg - Campus 1 53127 Bonn

dwachten@uni-bonn.de

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We aim to understand how cilia work and what their function is. Cilia are subcellular compartments that protrude from the surface of almost every mammalian cell. Cilia can be grouped into two major classes: a) primary cilia, which are immotile and b) motile cilia, which are also called flagella. A prominent example for the latter are sperm flagella. Ciliary dysfunction leads to severe diseases commonly referred to as ciliopathies. They comprise e.g. polycystic kidney disease, obesity, blindness, and infertility. However, the signaling pathways controlling ciliary function are ill-defined. To study ciliary signaling with high spatial and temporal precision, we combine optogenetics and genetically-encoded biosensors with high-resolution microscopy, mouse genetics, and biochemistry. This multidisciplinary approach allows not only to investigate ciliary signaling, but can be applied to any subcellular compartment to study its function with spatial and temporal resolution.

Dagmar Wachten

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Recent publications

  • A molecular mechanism to diversify Ca signaling downstream of Gs protein-coupled receptors.

    Nature communications

    Authors: Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis

  • Top publication

    From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists.

    Scientific data

    Authors: Lea Seep, Stephan Grein, Iva Splichalova, Danli Ran, Mickel Mikhael, Staffan Hildebrand, Mario Lauterbach, Karsten Hiller, Dalila Juliana Silva Ribeiro, Katharina Sieckmann, Ronja Kardinal, Hao Huang, Jiangyan Yu, Sebastian Kallabis, Janina Behrens, Andreas Till, Viktoriya Peeva, Akim Strohmeyer, Johanna Bruder, Tobias Blum, Ana Soriano-Arroquia, Dominik Tischer, Katharina Kuellmer, Yuanfang Li, Marc Beyer, Anne-Kathrin Gellner, Tobias Fromme, Henning Wackerhage, Martin Klingenspor, Wiebke K Fenske, Ludger Scheja, Felix Meissner, Andreas Schlitzer, Elvira Mass, Dagmar Wachten, Eicke Latz, Alexander Pfeifer, Jan Hasenauer

  • Opposing roles of resident and infiltrating immune cells in the defence against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice.

    Mucosal immunology

    Authors: Lara M Oberkircher, Victoria M Scheiding, H Linda Rafeld, Eric Hanssen, Jan N Hansen, Markus J Fleischmann, Nina Kessler, David Pitsch, Dagmar Wachten, Wolfgang Kastenmüller, Andrew S Brown, Elizabeth L Hartland, Ian R van Driel, Garrett Z Ng, Natalio Garbi

All publications by Prof. Dr. Dagmar Wachten