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PD Dr. Gregor Hagelüken

Member

Institute of Structural Biology

University Bonn, Institute of Structural Biology, Sigmund-Freud-Str. 25, D-53127 Bonn

hagelueken@uni-bonn.de

+49 228 28751200

Website

The research in my group focuses on two related topics. The first topic is bacterial immunity. The discovery of CRISPR defense systems has shown that bacteria have very complicated immune systems that protect the microorganisms from attack by phages, i.e. viruses that are specialized to infect bacteria. In addition to CRISPR, there are many other bacterial defense systems, many of which are strikingly similar to parts of the human immune system.
The second theme is the interface between pathogens and our immune system, such as the tricks that pathogens use to evade the latter. One example is a process by which pathogens such as Haemophilus influenzae scavenge a sugar molecule called sialic acid from our tissues and incorporate it into their cell wall to hide from our immune system.
Using general biochemistry and structural biology, we are trying to understand these systems and learn about the origin and function of our immune system.

Gregor Hagelüken

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Recent publications

  • Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models.

    European journal of human genetics : EJHG

    Authors: Nina Ishorst, Selina Hölzel, Carola Greve, Öznur Yilmaz, Tobias Lindenberg, Jessica Lambertz, Dmitriy Drichel, Berina Zametica, Enrico Mingardo, Jeshurun C Kalanithy, Khadija Channab, Duygu Kibris, Sabrina Henne, Franziska Degenhardt, Anna Siewert, Michael Dixon, Teresa Kruse, Edwin Ongkosuwito, Katta M Girisha, Shruti Pande, Stefanie Nowak, Gregor Hagelueken, Matthias Geyer, Carine Carels, Iris A L M van Rooij, Kerstin U Ludwig, Benjamin Odermatt, Elisabeth Mangold

  • Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein.

    Communications biology

    Authors: Niels Schneberger, Philipp Hendricks, Martin F Peter, Erik Gehrke, Sophie C Binder, Paul-Albert Koenig, Stephan Menzel, Gavin H Thomas, Gregor Hagelueken

  • Cryo-EM structure of the human native plasma coagulation factor XIII complex.

    Blood

    Authors: Sneha Singh, Gregor Hagelueken, Deniz Ugurlar, Samhitha Urs Ramaraje Urs, Amit Sharma, Manoranjan Mahapatra, Friedel Drepper, Diana Imhof, Pitter F Huesgen, Johannes Oldenburg, Matthias Geyer, Arijit Biswas

All publications by PD Dr. Gregor Hagelüken