Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation.
EMBO molecular medicine
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My group has focused on fluid biomarkers for the detection of different neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, Frontotemporal Dementia and Amyotrophic Lateral Sclerosis, especially in early, preclinical disease stages. In particular, we are interested in extracellular vesicles, not only as biomarkers but also as modulators of inflammation, their role in cell-cell communication and as potential carriers of disease pathology in neurodegeneration. We are employing data and biomaterial from patient cohorts as well as cell culture and murine models to elucidate the contribution of microglia to disease pathology in Alzheimer’s and Parkinson’s disease.
EMBO molecular medicine
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View this publicationFrontiers in aging neuroscience
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