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Prof. Dr. Christian Bode

Member

Clinic for Anesthesiology and Operative Intensive Medicine

Venusberg-Campus 1, 53127 Bonn

christian.bode@ukbonn.de

+49 228 28114119

Our research focuses on the molecular and cellular mechanisms underlying immune responses in inflammatory diseases of critical ill patients, including Systemic Inflammatory Response Syndrome (SIRS), sepsis, and Acute Respiratory Distress Syndrome (ARDS). Through a translational approach, we explore the regulation of the innate immune response, particularly how danger- and pathogen-associated molecular patterns (DAMPs and PAMPs) are recognized and how their activated signaling pathways can be modulated. A key aspect of our work is understanding the variability of individual immune responses, with the ultimate goal of developing personalized treatments to prevent and manage organ failure in the context of critical illness.

Prof. Dr. Christian Bode

Recent publications

  • Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy.

    Signal transduction and targeted therapy

    Authors: Zhaorong Chen, Rayk Behrendt, Lennart Wild, Martin Schlee, Christian Bode

  • The effect of therapeutic plasma exchange on the inflammatory response in septic shock: a secondary analysis of the EXCHANGE-1 trial.

    Intensive care medicine experimental

    Authors: Andrea Sauer, Klaus Stahl, Benjamin Seeliger, Pedro David Wendel-Garcia, Felix Lehmann, Julius J Schmidt, Bernhard M W Schmidt, Tobias Welte, Konrad Peukert, Lennart Wild, Christian Putensen, Sascha David, Christian Bode

  • Retrospective analysis of 300 microbial cell-free DNA sequencing results in routine blood stream infection diagnostics.

    Frontiers in cellular and infection microbiology

    Authors: Claudio Neidhöfer, Niklas Klein, Aylin Yürüktümen, Tessa Hattenhauer, Rebekka Mispelbaum, Christian Bode, Tobias A W Holderried, Achim Hoerauf, Marijo Parčina

All publications by Prof. Dr. Christian Bode