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Prof. Dr. Eicke Latz

Member

Institute of Innate Immunity

Medical Faculty, University of Bonn University Hospital of Bonn Biomedical Center, 1G007 Sigmund-Freud-Strasse 25 53127 Bonn

eicke.latz@uni-bonn.de

+49 1515 8233370

Website

The Latz Lab has a longstanding interest in deciphering the molecular
mechanisms of innate immune receptor activation. In particular, the lab
is interested in understanding how innate receptors interact with their
ligands and how this molecular interaction leads to receptor activation.
Recently, we have also focused on the molecular details of the
mechanisms that lead to the activation of the NLRP3 and AIM2
inflammasome. The NLRP3 inflammasome can respond to a broad range of
cellular stressors and to substances that indicate metabolic
derangements such as aggregated peptides, crystals of monosodium urate
(forming in gout) or crystals of cholesterol that are found in
atherosclerotic plaques. One goal of the research is to translate the
molecular understanding of innate immune receptor activation into the
generation of molecular tools that could lead to the development of
specific diagnostics for inflammatory materials. Another goal is to
devise means to pharmacologically interfere with the activation of
innate immune receptors in order to develop novel approaches to treat
inflammatory diseases such as Alzheimer’s disease or atherosclerosis.

Eicke Latz

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Recent publications

  • Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway.

    Cell reports

    Authors: Alexandra Ehrens, Benjamin Lenz, Celia Nieto-Pérez, Eicke Latz, Florian I Schmidt, Achim Hoerauf, Marc P Hübner

  • Systematic assessment of COVID-19 host genetics using whole genome sequencing data.

    PLoS pathogens

    Authors: Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov, Elaheh Vojgani, Ayda Abolhassani, Rana Aldisi, Guillaume Butler-Laporte, T Madhusankha Alawathurage, Max Augustin, Robert Bals, Carla Bellinghausen, Marc Moritz Berger, Michael Bitzer, Christian Bode, Jannik Boos, Thorsten Brenner, Oliver A Cornely, Thomas Eggermann, Johanna Erber, Torsten Feldt, Christian Fuchsberger, Julien Gagneur, Siri Göpel, Tobias Haack, Helene Häberle, Frank Hanses, Julia Heggemann, Ute Hehr, Johannes C Hellmuth, Christian Herr, Anke Hinney, Per Hoffmann, Thomas Illig, Björn-Erik Ole Jensen, Verena Keitel, Sarah Kim-Hellmuth, Philipp Koehler, Ingo Kurth, Anna-Lisa Lanz, Eicke Latz, Clara Lehmann, Tom Luedde, Carlo Maj, Michael Mian, Abigail Miller, Maximilian Muenchhoff, Isabell Pink, Ulrike Protzer, Hana Rohn, Jan Rybniker, Federica Scaggiante, Anna Schaffeldt, Clemens Scherer, Maximilian Schieck, Susanne V Schmidt, Philipp Schommers, Christoph D Spinner, Maria J G T Vehreschild, Thirumalaisamy P Velavan, Sonja Volland, Sibylle Wilfling, Christof Winter, J Brent Richards, André Heimbach, Kerstin Becker, Stephan Ossowski, Joachim L Schultze, Peter Nürnberg, Markus M Nöthen, Susanne Motameny, Michael Nothnagel, Olaf Riess, Eva C Schulte, Kerstin U Ludwig

  • NIS-Seq enables cell-type-agnostic optical perturbation screening.

    Nature biotechnology

    Authors: Caroline I Fandrey, Marius Jentzsch, Peter Konopka, Alexander Hoch, Katja Blumenstock, Afraa Zackria, Salie Maasewerd, Marta Lovotti, Dorothee J Lapp, Florian N Gohr, Piotr Suwara, Jędrzej Świeżewski, Lukas Rossnagel, Fabienne Gobs, Maia Cristodaro, Lina Muhandes, Rayk Behrendt, Martin C Lam, Klaus J Walgenbach, Tobias Bald, Florian I Schmidt, Eicke Latz, Jonathan L Schmid-Burgk

All publications by Prof. Dr. Eicke Latz