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Prof. Dr. Hiroki Kato

Member, Steering-Committee Member

Institute of Cardiovascular Immunology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

hkato@uni-bonn.de

Website

My research focuses on the mechanisms by which cytoplasmic RNA sensors RIG-I like receptors (RLRs) distinguish between viral RNAs and self-RNAs and trigger type I IFNs. Current work examines spontaneous autoimmune symptoms in RLR mutant mice derived via mutagenesis and how RLR-dysregulation causes autoimmune disease. I am also particularly interested in the analysis of immune responses and pathogenesis in virus infection in vivo and autoimmune diseases using mouse models.

Hiroki Kato

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Recent publications

  • Soluble form of the MDA5 protein in human sera.

    Heliyon

    Authors: Masaki Okamoto, Yoshiaki Zaizen, Shinjiro Kaieda, Takashi Nouno, Takuma Koga, Goushi Matama, Masahiro Mitsuoka, Jun Akiba, Shintaro Yamada, Hiroki Kato, Tomoaki Hoshino

  • Physiological functions of RIG-I-like receptors.

    Immunity

    Authors: Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita

  • Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity.

    Science advances

    Authors: Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato

All publications by Prof. Dr. Hiroki Kato