Skip to main content

Prof. Dr. Hiroki Kato

Member, Steering-Committee Member

Institute of Cardiovascular Immunology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

hkato@uni-bonn.de

Website

My research focuses on the mechanisms by which cytoplasmic RNA sensors RIG-I like receptors (RLRs) distinguish between viral RNAs and self-RNAs and trigger type I IFNs. Current work examines spontaneous autoimmune symptoms in RLR mutant mice derived via mutagenesis and how RLR-dysregulation causes autoimmune disease. I am also particularly interested in the analysis of immune responses and pathogenesis in virus infection in vivo and autoimmune diseases using mouse models.

Hiroki Kato

Download biosketch

Recent publications

  • RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.

    The EMBO journal

    Authors: Alexander Kirchhoff, Anna-Maria Herzner, Christian Urban, Antonio Piras, Robert Düster, Julia Mahlberg, Agathe Grünewald, Thais M Schlee-Guimarães, Katrin Ciupka, Petro Leka, Robert J Bootz, Christina Wallerath, Charlotte Hunkler, Ann Kristin de Regt, Beate M Kümmerer, Maria Hønholt Christensen, Florian I Schmidt, Min Ae Lee-Kirsch, Claudia Günther, Hiroki Kato, Eva Bartok, Gunther Hartmann, Matthias Geyer, Andreas Pichlmair, Martin Schlee

  • Mouse models of type I interferonopathies.

    Human molecular genetics

    Authors: Domnica Luca, Hiroki Kato

  • Soluble form of the MDA5 protein in human sera.

    Heliyon

    Authors: Masaki Okamoto, Yoshiaki Zaizen, Shinjiro Kaieda, Takashi Nouno, Takuma Koga, Goushi Matama, Masahiro Mitsuoka, Jun Akiba, Shintaro Yamada, Hiroki Kato, Tomoaki Hoshino

All publications by Prof. Dr. Hiroki Kato