Benchmarking methods for computing local sensitivities in ordinary differential equation models at dynamic and steady states.
PloS one
View this publicationLife and Medical Sciences Institute (LIMES) and Hausdorff Center for Mathematics
Hausdorff Center for Mathematics - HCM Room 2.003 Villa Maria, Endenicher Allee 64 53115 Bonn
Our interdisciplinary research unit develops and applies computational methods for the analysis of complex biological processes. We focus on methods facilitating the model-based integration of different datasets, the critical assessment of the availableinformation, the comparison of competing biological hypothesis and the tailored selection of future experiments. Following thephilosophy of Galileo Galilei: "Measure what can be measured, and make measurable what cannot be measured.", we usemodels to reconstruct properties of the system which cannot be assessed experimentally. This results in an improved holisticunderstanding of biological systems. We apply these methods to study cellular signal processing, cell-to-cell variability, and tissueorganisation.
Recent publications
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Federated difference-in-differences with multiple time periods in DataSHIELD.
iScience
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Machine Learning Methods for Precision Dosing in Anticancer Drug Therapy: A Scoping Review.
Clinical pharmacokinetics
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