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Prof. Dr. Katrin Paeschke

Member, Steering-Committee Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53105 Bonn

katrin.paeschke@ukbonn.de

Website

Katrin Paeschke's research focuses on specific DNA and RNA structures named G-quadruplexes (G4s). These structures form within all living cells including virus where they support cellular functions. The Paeschke group aims to characterise how DNA and RNA G-quadruplex structures are recognised and regulated by proteins.We utilise a combination of molecular, biochemical and global experimental approaches (ChIP-seq, ATAC-seq, Cut & Tag, RNA-seq, PAR-CLIP) to better understand the molecular network and contribution of G4s for genome stability and cellular functions in living cells. We also aim to characterise how G4-protein interactions (both on DNA and RNA levels) contribute to the immune response activation and how these structures can modulate the immune response.

Katrin Paeschke

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Recent publications

  • Poly (ADP-ribose) polymerase in yeasts: characterization and involvement in telomere maintenance.

    Nucleic acids research

    Authors: Regina Sepšiová, Katarína Procházková, Filip Červenák, Denis Majerčík, Kateřina Hanáková, Erika Lattová, Mona Hajikazemi, Zbyněk Zdráhal, Sofia Virágová, Zuzana Brzáčová, Katrin Paeschke, Jozef Nosek, Ľubomír Tomáška

  • The Shu complex interacts with the replicative helicase to prevent mutations and aberrant recombination.

    The EMBO journal

    Authors: Adeola A Fagunloye, Alessio De Magis, Jordan H Little, Isabela Contreras, Tanis J Dorwart, Braulio Bonilla, Kushol Gupta, Nathan Clark, Theresa Zacheja, Katrin Paeschke, Kara A Bernstein

  • Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control.

    Cell host & microbe

    Authors: Philipp Schult, Beate Mareike Kümmerer, Markus Hafner, Katrin Paeschke

All publications by Prof. Dr. Katrin Paeschke