Skip to main content

Prof. Dr. Matthias Geyer

Member, Steering-Committee Member

Institute of Structural Biology

University Bonn, Department of Structural Immunology, Sigmund-Freud-Str. 25, D-53127 Bonn

matthias.geyer@uni-bonn.de

+49 228 28751400

Website

The Geyer lab is interested in the regulation of transcription and the molecular mechanisms that govern immune receptor activation. We use a variety of techniques from molecular biology and biochemistry to structural biology to analyze interaction between proteins, RNA, lipids, and ligands. The transcription cycle is regulated by cyclin-dependent kinases that phosphorylate the RNA polymerase II. We analyze the transition from transcription initiation to productive elongation in eukaryotic cells. We study the molecular and structural mechanisms that determine the activity and regulation of transcription-controlling kinases, as well as their inhibition by small molecular compounds. We recently also focused on the analysis of receptor activation of NLRP3 and forma-tion of the NLRP3/ASC/caspase inflammasome. Besides NACHT-domain containing proteins, Toll-like receptors, RIG-I and the cGAS-STING pathway mediate the immune-recogni-tion of pathogens. We aim at identifying target sites in these immune regulators that allow for the specific interference with the immune system, e.g., by small molecular compounds.

Matthias Geyer

Download biosketch

Recent publications

  • Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants.

    Nature immunology

    Authors: Shouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L Masters

  • Degrading the key component of the inflammasome: development of an NLRP3 PROTAC.

    Chemical communications (Cambridge, England)

    Authors: Tim Keuler, Dominic Ferber, Jonas Engelhardt, Christian Steinebach, Nico Kirsch, Michael Marleaux, Günther Weindl, Matthias Geyer, Michael Gütschow

  • RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.

    The EMBO journal

    Authors: Alexander Kirchhoff, Anna-Maria Herzner, Christian Urban, Antonio Piras, Robert Düster, Julia Mahlberg, Agathe Grünewald, Thais M Schlee-Guimarães, Katrin Ciupka, Petro Leka, Robert J Bootz, Christina Wallerath, Charlotte Hunkler, Ann Kristin de Regt, Beate M Kümmerer, Maria Hønholt Christensen, Florian I Schmidt, Min Ae Lee-Kirsch, Claudia Günther, Hiroki Kato, Eva Bartok, Gunther Hartmann, Matthias Geyer, Andreas Pichlmair, Martin Schlee

All publications by Prof. Dr. Matthias Geyer