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Prof. Dr. med. Gunther Hartmann

Speaker, Member, Steering-Committee Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg - Campus 1 53127 Bonn

gunther.hartmann@ukbonn.de

+49 228 28716080

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For over 20 years, Prof Hartmann’s research focus has been nucleic acid sensing in the broader context of nucleic acid immunity, and he has made fundamental contributions to the identification, characterization and immunobiology of nucleic acid ligands of TLR7, TLR8, TLR9, RIG-I, STING and cGAS. His group has discovered a pivotal mechanism by which RIG-I discriminates between foreign and self RNA, which is highly relevant for the development of improved mRNA vaccines. He has characterized the role of NLRP3 in NK-cell memory, has contributed to the discovery of cyclic [G(2’,5’) pA(3’,5’)p] (cGAMP), the metazoan second messenger in the cGAS- STING pathway, and to the identification of Y-form DNA as a minimal ligand for cGAS, and has demonstrated that RIG-I-triggered innate antiviral immunity can be used for prophylaxis and for treatment of viral infections such as influenza and SARS-CoV-2 in vivo.

Gunther Hartmann

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Recent publications

  • Isolation and characterization of extracellular vesicles from EGFR mutated lung cancer cells.

    Clinical and experimental medicine

    Authors: Dian Jamel Salih, Katrin S Reiners, Roberta Alfieri, Ahmed Mohammed Salih, Zulema Antonia Percario, Mariantonietta Di Stefano, Sollitto Francesco, Elisabetta Affabris, Gunther Hartmann, Teresa Santantonio

  • Immunoengineering of a Photocaged 5´-triphosphate Oligoribonucleotide Ligand for Spatiotemporal Control of RIG-I Activation in Cancer.

    Angewandte Chemie (International ed. in English)

    Authors: Sandra Lewash, Vivien McKenney, Christine Wuebben, Janos Ludwig, Racha Hosni, Dirk Radzey, Marieta Toma, Martin Schlee, Eva Bartok, Thomas Zillinger, Alexander Heckel, Gunther Hartmann

  • Immune training enhances anti-viral responses and improves outcomes in Pax5 mice susceptible to chronic infection.

    EMBO molecular medicine

    Authors: Zhe Lu, Olivia Stencel, Wei Liu, Eleni Vasileiou, Haifeng C Xu, Piyush Pandey, Paweł Stachura, Abdelrahman Elwy, Anastassia Tsombal, Ann-Sophie Mai, Franziska Auer, Mina N F Morcos, Maximilian Seidl, Sarah Koziel, Peter-Martin Bruch, Sascha Dietrich, Sarah Elitzur, Gunther Hartmann, Karl S Lang, Stefan Janssen, Ute Fischer, Sanil Bhatia, Philipp A Lang, Arndt Borkhardt, Julia Hauer, Aleksandra A Pandyra

All publications by Prof. Dr. med. Gunther Hartmann