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Prof. Dr. med. Gunther Hartmann

Speaker, Member, Steering-Committee Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg - Campus 1 53127 Bonn

gunther.hartmann@ukbonn.de

+49 228 28716080

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For over 20 years, Prof Hartmann’s research focus has been nucleic acid sensing in the broader context of nucleic acid immunity, and he has made fundamental contributions to the identification, characterization and immunobiology of nucleic acid ligands of TLR7, TLR8, TLR9, RIG-I, STING and cGAS. His group has discovered a pivotal mechanism by which RIG-I discriminates between foreign and self RNA, which is highly relevant for the development of improved mRNA vaccines. He has characterized the role of NLRP3 in NK-cell memory, has contributed to the discovery of cyclic [G(2’,5’) pA(3’,5’)p] (cGAMP), the metazoan second messenger in the cGAS- STING pathway, and to the identification of Y-form DNA as a minimal ligand for cGAS, and has demonstrated that RIG-I-triggered innate antiviral immunity can be used for prophylaxis and for treatment of viral infections such as influenza and SARS-CoV-2 in vivo.

Gunther Hartmann

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Recent publications

  • ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA.

    Cell reports

    Authors: Ole Kristian Greiner-Tollersrud, Máté Krausz, Vincent Boehler, Aikaterini Polyzou, Maximilian Seidl, Ambra Spahiu, Zeinab Abdullah, Katarzyna Andryka-Cegielski, Felix Immunuel Dominick, Katrin Huebscher, Andreas Goschin, Cristian R Smulski, Eirini Trompouki, Regina Link, Hilmar Ebersbach, Honnappa Srinivas, Martine Marchant, Georgios Sogkas, Dieter Staab, Cathrine Vågbø, Danilo Guerini, Sebastian Baasch, Eicke Latz, Gunther Hartmann, Philippe Henneke, Roger Geiger, Xiao P Peng, Bodo Grimbacher, Eva Bartok, Ingrun Alseth, Max Warncke, Michele Proietti

  • Synthetic RIG-I agonist-mediated cancer immunotherapy synergizes with MAP kinase inhibition against BRAF-mutated melanoma.

    Molecular therapy. Nucleic acids

    Authors: Christian Grützner, Yu Pan Tan, Patrick Müller, Thais M Schlee-Guimaraes, Marius Jentzsch, Jonathan L Schmid-Burgk, Marcel Renn, Rayk Behrendt, Gunther Hartmann

  • Induction and antiviral activity of ferret myxovirus resistance (Mx) protein 1 against influenza A viruses.

    Scientific reports

    Authors: Rubaiyea Farrukee, Lara S U Schwab, James B Barnes, Andrew G Brooks, Sarah L Londrigan, Gunther Hartmann, Thomas Zillinger, Patrick C Reading

All publications by Prof. Dr. med. Gunther Hartmann