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Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

michael.hoelzel@ukbonn.de

+49 228 28751393

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Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Michael Hölzel

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Recent publications

  • MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma.

    Acta neuropathologica

    Authors: Lea L Friker, Thomas Perwein, Andreas Waha, Evelyn Dörner, Rebecca Klein, Mirjam Blattner-Johnson, Julian P Layer, Dominik Sturm, Gunther Nussbaumer, Robert Kwiecien, Isabel Spier, Stefan Aretz, Kornelius Kerl, Ulrike Hennewig, Marius Rohde, Axel Karow, Ingmar Bluemcke, Ann Kristin Schmitz, Harald Reinhard, Pablo Hernáiz Driever, Susanne Wendt, Annette Weiser, Ana S Guerreiro Stücklin, Nicolas U Gerber, André O von Bueren, Claudia Khurana, Norbert Jorch, Maria Wiese, Christian P Kratz, Matthias Eyrich, Michael Karremann, Ulrich Herrlinger, Michael Hölzel, David T W Jones, Marion Hoffmann, Torsten Pietsch, Gerrit H Gielen, Christof M Kramm

  • RNase T2 restricts TLR13-mediated autoinflammation in vivo.

    The Journal of experimental medicine

    Authors: Carlos Gomez-Diaz, Wilhelm Greulich, Benedikt Wefers, Meiyue Wang, Silvia Bolsega, Maike Effern, Daniel P Varga, Zhe Han, Minyi Chen, Marleen Bérouti, Natascia Leonardi, Ulrike Schillinger, Bernhard Holzmann, Arthur Liesz, Axel Roers, Michael Hölzel, Marijana Basic, Wolfgang Wurst, Veit Hornung

  • Dissection of Progressive Disease Patterns for a Modified Classification for Immunotherapy.

    JAMA oncology

    Authors: Jonas Saal, Markus Eckstein, Manuel Ritter, Peter Brossart, Julian Luetkens, Jörg Ellinger, Viktor Grünwald, Michael Hölzel, Niklas Klümper

All publications by Prof. Dr. Michael Hölzel