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Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

michael.hoelzel@ukbonn.de

+49 228 28751393

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Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Michael Hölzel

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Recent publications

  • Dissection of Progressive Disease Patterns for a Modified Classification for Immunotherapy.

    JAMA oncology

    Authors: Jonas Saal, Markus Eckstein, Manuel Ritter, Peter Brossart, Julian Luetkens, Jörg Ellinger, Viktor Grünwald, Michael Hölzel, Niklas Klümper

  • C-Reactive Protein Facilitates Premetastatic Niche Formation in the Lungs.

    Cancer research

    Authors: Jonas Saal, Niklas Klümper, Michael Hölzel

  • Tonabersat enhances temozolomide-mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition.

    Molecular oncology

    Authors: Elena N C Schmidt, Bernd O Evert, Barbara E F Pregler, Ahmad Melhem, Meng-Chun Hsieh, Markus Raspe, Hannah Strobel, Julian Roos, Torsten Pietsch, Patrick Schuss, Pamela Fischer-Posovszky, Mike-Andrew Westhoff, Michael Hölzel, Ulrich Herrlinger, Hartmut Vatter, Andreas Waha, Matthias Schneider, Anna-Laura Potthoff

All publications by Prof. Dr. Michael Hölzel