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Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

michael.hoelzel@ukbonn.de

+49 228 28751393

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Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Michael Hölzel

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Recent publications

  • Type I Interferon Drives a Cellular State Inert to TCR-Stimulation and Could Impede Effective T-Cell Differentiation in Cancer.

    European journal of immunology

    Authors: Dillon Corvino, Martin Batstone, Brett G M Hughes, Tim Kempchen, Susanna S Ng, Nazhifah Salim, Franziska Schneppenheim, Denise Rommel, Ananthi Kumar, Sally Pearson, Jason Madore, Lambross T Koufariotis, Lisa Maria Steinheuer, Dilan Pathirana, Kevin Thurley, Michael Hölzel, Nicholas Borcherding, Matthias Braun, Tobias Bald

  • Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer.

    Nature reviews. Urology

    Authors: Niklas Klümper, Alexander Cox, Gottfrid Sjödahl, Florian Roghmann, Christian Bolenz, Arndt Hartmann, Viktor Grünwald, Bishoy M Faltas, Michael Hölzel, Markus Eckstein

  • HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevance.

    Frontiers in immunology

    Authors: Annalena Branz, Christian Matek, Fabienne Lange, Veronika Bahlinger, Niklas Klümper, Michael Hölzel, Pamela L Strissel, Reiner Strick, Danijel Sikic, Sven Wach, Helge Taubert, Bernd Wullich, Arndt Hartmann, Barbara Seliger, Markus Eckstein

All publications by Prof. Dr. Michael Hölzel