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Prof. Dr. Özgün Gökce

Member

Medical Faculty, University of Bonn & German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1/99 D-53127 Bonn Germany

Ozgun.Goekce@ukbonn.de

Website

Our research group represents a synergistic fusion of multi disciplinary expertise, striving to unravel the complexities of age-related brain disorders through the development of cutting-edge quantitative genomics techniques. Our mission is to decode the cellular responses underlying the aging process and to dissect the molecular mechanisms driving neurodevelopmental and neurodegenerative disorders. To achieve these objectives, we develop and integrate state-of-the-art technologies, including single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), electron microscopy, and machine learning algorithms, forging a comprehensive and holistic understanding of these critical biological processes.

Ozgun Gokce

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Recent publications

  • Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system.

    Immunity

    Authors: Vini Tiwari, Bharat Prajapati, Yaw Asare, Alkmini Damkou, Hao Ji, Lu Liu, Nawraa Naser, Garyfallia Gouna, Katarzyna B Leszczyńska, Jakub Mieczkowski, Martin Dichgans, Qing Wang, Riki Kawaguchi, Zechuan Shi, Vivek Swarup, Daniel H Geschwind, Marco Prinz, Ozgun Gokce, Mikael Simons

  • Innate immune memory after brain injury drives inflammatory cardiac dysfunction.

    Cell

    Authors: Alba Simats, Sijia Zhang, Denise Messerer, Faye Chong, Sude Beşkardeş, Aparna Sharma Chivukula, Jiayu Cao, Simon Besson-Girard, Felipe A Montellano, Caroline Morbach, Olga Carofiglio, Alessio Ricci, Stefan Roth, Gemma Llovera, Rashween Singh, Yiming Chen, Severin Filser, Nikolaus Plesnila, Christian Braun, Hannah Spitzer, Ozgun Gokce, Martin Dichgans, Peter U Heuschmann, Kinta Hatakeyama, Eduardo Beltrán, Sebastian Clauss, Boyan Bonev, Christian Schulz, Arthur Liesz

  • T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

    Nature neuroscience

    Authors: Shreeya Kedia, Hao Ji, Ruoqing Feng, Peter Androvic, Lena Spieth, Lu Liu, Jonas Franz, Hanna Zdiarstek, Katrin Perez Anderson, Cem Kaboglu, Qian Liu, Nicola Mattugini, Fatma Cherif, Danilo Prtvar, Ludovico Cantuti-Castelvetri, Arthur Liesz, Martina Schifferer, Christine Stadelmann, Sabina Tahirovic, Ozgun Gokce, Mikael Simons

All publications by Prof. Dr. Özgün Gökce