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Prof. Dr. Rayk Behrendt

Member, Steering-Committee Member

Institute of Clinical Chemistry and Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg-Campus 1 53105 Bonn

behrendt@uni-bonn.de

Website

We investigate under which conditions endogenous nucleic acids can activate nucleic acid sensors of the innate immune system. Over the last 20 years innate immune recognition of nucleic acids has been established as a central mechanism driving inflammation of sterile and of infectious etiologies. In the future, we will build upon the knowledge gained from studying disease to understand the role of nucleic acid immunity in health.

Rayk_Behrendt

Recent publications

  • Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling.

    eLife

    Authors: Hella Luksch, Felix Schulze, David Geißler-Lösch, David Sprott, Lennart Höfs, Eva M Szegö, Wulf Tonnus, Stefan Winkler, Claudia Günther, Andreas Linkermann, Rayk Behrendt, Lino L Teichmann, Björn H Falkenburger, Angela Rösen-Wolff

  • Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy.

    Signal transduction and targeted therapy

    Authors: Zhaorong Chen, Rayk Behrendt, Lennart Wild, Martin Schlee, Christian Bode

  • The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis.

    Cellular and molecular life sciences : CMLS

    Authors: Onur Kerem Tever, Torben Mentrup, Ivan Kingyue Chinn, Hitoshi Ishikuma, Regina Fluhrer, Marc Schmitz, Rebekka Wehner, Rayk Behrendt, Javier Chinen, Bernd Schröder

All publications by Prof. Dr. Rayk Behrendt