Skip to main content

Prof. Dr. Rayk Behrendt

Member, Steering-Committee Member

Institute of Clinical Chemistry and Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg-Campus 1 53105 Bonn

behrendt@uni-bonn.de

Website

We investigate under which conditions endogenous nucleic acids can activate nucleic acid sensors of the innate immune system. Over the last 20 years innate immune recognition of nucleic acids has been established as a central mechanism driving inflammation of sterile and of infectious etiologies. In the future, we will build upon the knowledge gained from studying disease to understand the role of nucleic acid immunity in health.

Rayk_Behrendt

Recent publications

  • Synthetic RIG-I agonist-mediated cancer immunotherapy synergizes with MAP kinase inhibition against BRAF-mutated melanoma.

    Molecular therapy. Nucleic acids

    Authors: Christian Grützner, Yu Pan Tan, Patrick Müller, Thais M Schlee-Guimaraes, Marius Jentzsch, Jonathan L Schmid-Burgk, Marcel Renn, Rayk Behrendt, Gunther Hartmann

  • Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity.

    Science advances

    Authors: Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato

  • Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.

    Molecular therapy : the journal of the American Society of Gene Therapy

    Authors: Erika Valeri, Giulia Unali, Francesco Piras, Monah Abou-Alezz, Giulia Pais, Fabrizio Benedicenti, Maria Rosa Lidonnici, Ivan Cuccovillo, Ilaria Castiglioni, Sergio Arévalo, Giulio Spinozzi, Ivan Merelli, Rayk Behrendt, Adrian Oo, Baek Kim, Nathaniel R Landau, Giuliana Ferrari, Eugenio Montini, Anna Kajaste-Rudnitski

All publications by Prof. Dr. Rayk Behrendt