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Prof. Dr. Sven Wehner

Member, Steering-Committee Member

Department of Surgery

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

Sven.Wehner@ukbonn.de

+49 228 28711007

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The aim of our research is to identify (neuro)-immunological mechanisms contributing to acute (postoperative) and chronic functional disturbances of the GI tract. In a series of publications our group demonstrated that interactions of resident immune cells and the enteric nervous system trigger postoperative bowel wall inflammation. This local neuroinflammation can be effectively modified by intrinsic and extrinsic neurotransmitters. With international collaborators we also investigate the neuroimmunology of chronic inflammatory bowel diseases. Currently, we are aiming to understand the initial trigger mechanisms of intestinal inflammation as well as to identify novel neuro-immune modulatory pathways. This will help us to gather a comprehensive understanding of acute and chronic intestinal inflammatory disorders.

Sven Wehner

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Recent publications

  • Layer-specific molecular signatures of colon anastomotic healing and leakage in mice.

    Molecular medicine (Cambridge, Mass.)

    Authors: Hilal Sengul, Vasiliki Bantavi, Laura Gloeck, Andrew Y F Li Yim, Patrick Leven, Patrik Efferz, Bianca Schneiker, Mariola Lysson, Wouter J De Jonge, Sven Wehner

  • Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation.

    EMBO molecular medicine

    Authors: Mona Breßer, Kevin D Siemens, Linda Schneider, Jonah E Lunnebach, Patrick Leven, Tim R Glowka, Kristin Oberländer, Elena De Domenico, Joachim L Schultze, Joachim Schmidt, Jörg C Kalff, Anja Schneider, Sven Wehner, Reiner Schneider

  • Extracellular matrix substrates differentially influence enteric glial cell homeostasis and immune reactivity.

    Frontiers in immunology

    Authors: Linda Schneider, Reiner Schneider, Ebrahim Hamza, Sven Wehner

All publications by Prof. Dr. Sven Wehner