Aberrant hippocampal Ca microwaves following synapsin-dependent adeno-associated viral expression of Ca indicators.
eLife
View this publicationGerman Center for Neurodegenerative Diseases (DZNE)
Venusberg-Campus 1/99 53127 Bonn
My research focuses on neurologic and neurodegenerative diseases, like Alzheimer’s disease. I am interested in how the immune system interacts with the central nervous system. How do microglia – innate immune cells in the brain – interact with synapses and neurons, and how do the influence each other? Are microglia relevant for learning and memory and if so, how do they exert this function? To address these and other questions, we apply cutting edge multiphoton-based in vivo imaging methods in my lab. For example, it enables us to study neuronal activity in conjunction with microglia motility. In combination with optogenetic, chemogenetic, immunohistochemical, electrophysiological and behavior tests, we are able to causally link behavior to neuronal activity in brain regions relevant for learning and memory.
Recent publications
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Progress in Structural and Functional In Vivo Imaging of Microglia and Their Application in Health and Disease.
Advances in neurobiology
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Aberrant hippocampal Ca micro-waves following synapsin-dependent adenoviral expression of Ca indicators.
bioRxiv : the preprint server for biology
View this publication