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News Beck 10.2019
An interneuron (bright, with long appendages) from the hippocampus of the rat. The finely branched axon (top left cloud) surrounds the cell bodies of pyramidal cells and can inhibit these effectively.
© Leonie Pothmann/Uni Bonn

Publication

Epilepsy: Function of "brake cells" disrupted

In some forms of epilepsy, the function of certain "brake cells" in the brain is presumed to be disrupted. This may be one of the reasons why the electrical malfunction is able to spread from the point of origin across large parts of the brain. A current study by the University of Bonn with members of the cluster of excellence ImmunoSensation2, in which researchers from Lisbon were also involved, points in this direction. The results are published in the renowned "Journal of Neuroscience".

Publication

Leonie Pothmann, Christian Klos, Oliver Braganza, Sarah Schmidt, Oihane Horno, Raoul-Martin Memmesheimer and Heinz Beck: Altered dynamics of canonical feed-back inhibition predicts increased burst transmission in chronic epilepsy; The Journal Of Neuroscience; https://doi.org/10.1523/JNEUROSCI.2594-18.2019

Related news

Neurons - generated through the differentiation of induced neural stem cells (iNSCs) derived from blood.

Publication

Researchers Transform Old Blood Cells into Young Brain Cells

—Researchers from the University Hospital of Bonn and the University of Bonn have succeeded in dramatically rejuvenating human cells in a test tube. To do so, they directly reprogrammed red blood cell precursors into stem cells from which neurons can be derived. During this process, the molecular clocks that indicate a cell’s age were reset. For example, blood cells from an 80-year-old were transformed into stem cells with a molecular age of less than 20 years. The results have been published in the journal Aging Cell.
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Dr. Robert Hüneburg, Dr. Anne-Sophie Layritz, and Nicola Reents (from left) - conducted a survey and found that fewer than one in ten people with Lynch syndrome take Acetylsalicylic acid for cancer prevention – despite a high level of openness to new preventive approaches.

Publication

Aspirin Rarely Used for Colorectal Cancer Prevention

—According to international studies, taking Acetylsalicylic acid daily can protect people with Lynch syndrome from developing colorectal cancer – even at low doses. Researchers from the University Hospital Bonn (UKB), the University of Bonn, and the Center for Integrated Oncology (CIO) Bonn, in collaboration with the self-help organization SemiColon, have now found that these scientific findings have so far been insufficiently incorporated into clinical practice. The results of the LYNX study have now been published as a letter in the journal The Lancet Gastroenterology & Hepatology.
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Smartphone-based retinal imaging in clinical practice in India: - The image was taken during a collaborative project between University Hospital Bonn (UKB) and Sankara Eye Foundation India on smartphone-based telemedical screening for diabetic retinopathy.

Publication

Smartphones as Retinal Cameras: New Opportunities for Global Eye Care

—Smartphones could play an important role in the early detection of eye diseases, including in settings where specialized ophthalmic infrastructure is limited. An international team of experts led by the UKB and the University of Bonn has comprehensively reviewed the current global landscape of smartphone-based fundus imaging. The researchers highlight the technical and clinical possibilities that already exist today, identify the limitations of these methods, and outline the conditions that must be met so that smartphone-based retinal imaging can be more widely integrated into screening.
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