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News Beck 10.2019
An interneuron (bright, with long appendages) from the hippocampus of the rat. The finely branched axon (top left cloud) surrounds the cell bodies of pyramidal cells and can inhibit these effectively.
© Leonie Pothmann/Uni Bonn

Publication

Epilepsy: Function of "brake cells" disrupted

In some forms of epilepsy, the function of certain "brake cells" in the brain is presumed to be disrupted. This may be one of the reasons why the electrical malfunction is able to spread from the point of origin across large parts of the brain. A current study by the University of Bonn with members of the cluster of excellence ImmunoSensation2, in which researchers from Lisbon were also involved, points in this direction. The results are published in the renowned "Journal of Neuroscience".

Publication

Leonie Pothmann, Christian Klos, Oliver Braganza, Sarah Schmidt, Oihane Horno, Raoul-Martin Memmesheimer and Heinz Beck: Altered dynamics of canonical feed-back inhibition predicts increased burst transmission in chronic epilepsy; The Journal Of Neuroscience; https://doi.org/10.1523/JNEUROSCI.2594-18.2019

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Publication

New way to prevent duodenal cancer

—People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn have now discovered a mechanism in the local immune system that can drive the development of cancer. They see this as a promising new approach to preventing duodenal carcinoma in people with FAP. The results have now been published in the journal "Nature Communications".
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Publication

Starting points for the control of protein synthesis

—The research field of "cellular IRESes" lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated control of gene expression. Researchers at the University Hospital Bonn (UKB) and the University of Bonn, in collaboration with Stanford University in California (USA), have now developed a toolbox as a new gold standard for this field. The results of their work have been published in The EMBO Journal.
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Publication

Genetic mutation affects survival after viral infection

—Scientists discovered that haploinsufficiency in the Pax5 gene affects antiviral responses. The study was led by Prof. Dr. Aleksandra Pandyra from the Institute of Clinical Chemistry and Clinical Pharmacology at the University Hospital Bonn in collaboration with Prof. Dr. Arndt Borkhardt, Clinic Director at the Pediatric Oncology at the University Hospital Düsseldorf. The findings were published in the latest edition of EMBO Molecular Medicine.
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