This year marked the 68th scientific meeting of the “Gesellschaft für Thrombose- und Hämostaseforschung” (GTH) in Vienna, Austria with hundreds of guests from all over Europe. Amongst numerous compelling scientific presentations Dr. Janine Becker-Gotot from the Institute of Molecular Medicine and Experimental Immunology at the University Hospital Bonn stood out and secured the career development award for her groundbreaking work titled “Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs” that was published in the Journal of Clinical Investigation. The study uncovering a novel mechanism of peripheral antigen-specific B cell tolerance with potential applications as a biomarker received recognition for its translational impact.
In addition, the PhD student from the Becker-Gotot group Amina Adbelmageed received a poster award for her intriguing poster titled “Staphylococcus aureus infection restimulates inhibitor production in tolerized hemophilia A mice”. The study unravels the molecular mechanism responsible for the breakdown of tolerance during Immune Tolerance Therapy (ITI). This aspect, constituting an unresolved clinical challenge, compromises the effectiveness of the treatment.
Publication:
Janine Becker-Gotot, et al. (2022)
Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs
The Journal of Clinical Investigation
DOI: 10.1172/JCI159925
Contact:
Dr. Janine Becker-Gotot
Institute of Molecular Medicine and Experimental Immunology
University Hospital Bonn
E-Mail: jbecker-gotot@uni-bonn.de
