Skip to main content

Liver cells and western diet - regulating inflammation

A high fat Western-style diet leads to hepatic steatosis that can progress to liver cancer. Christoph Thiele (LIMES Institute) from the Cluster of Excellence ImmunoSensation and his colleagues used click chemistry-based metabolic tracing and microscopy, to study the interaction between Kupffer cells and hepatocytes ex vivo. The mechanism that leads to the development of steatosis upon nutritional overload is complex and only partially understood. Their study was recently published in the Journal of Cells and could show that inflammatory signals from liver cells upon western diet can lead to steatosis. The publication was shown on the cover of the journals edition in October.

Publication

Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation. Diehl et al., Cells (2020) 9(10), 2258, https://doi.org/10.3390/cells9102258

Related news

Scientists that contributed to the study

Publication

New way to prevent duodenal cancer

—People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn have now discovered a mechanism in the local immune system that can drive the development of cancer. They see this as a promising new approach to preventing duodenal carcinoma in people with FAP. The results have now been published in the journal "Nature Communications".
View entry
Kerstin Ludwig

Honors & Funding

Genome data to improve diagnosis and treatment of long Covid

—Despite the many advances, there are still major gaps in the care of patients with long-term and post-COVID. The Institute of Human Genetics at the UKB in Bonn now begins a genomLC study as part of a BMG funding priority. The researchers want to help speed up the diagnosis of long- and post-COVID and identify possible biomarkers that could possibly also differentiate between subgroups of the diseases. To this end, the genomic data of those affected is being analyzed as part of a study using blood samples. The project is funded by the Federal Ministry of Health (BMG) with 1.34 million euros.
View entry
Lab mouse

Event

“Transparent by nature” network meeting a complete success

—In order to communicate the importance of animal research transparently and promote an open exchange, Bonn research institutions joined forces to facilitate the exchange of all those who work with laboratory animals. The University of Bonn, together with other research institutions in Bonn, invited everyone who works with laboratory animals to the first network meeting “Naturally transparent” in the Poppelsdorf Auditorium Center. The aim of the event was to create a forum that strengthens the exchange of information on transparency in animal research and networking.
View entry

Back to the news overview