Macrophages have two faces: In healthy tissue, they perform important tasks and support their environment. However during an infection, they stop this work and hunt down the pathogens instead. Upon coming into contact with bacteria they change their metabolism drastically within minutes. This is shown by a new study under the leadership of the University of Bonn, which has now been published in the journal "Immunity". In the medium term, the results may lead to new vaccination strategies, but also to new approaches for combating autoimmune diseases.
The Study was lead by Cluster Member and Speaker Prof. Eicke Latz.
Publication
Mario A. Lauterbach, Jasmin E. Hanke, Magdalini Serefidou, Matthew S. J. Mangan, Carl-Christian Kolbe, Timo Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, Jan Gehlen, Gudrun Engels, Maike Kreutzenbeck, Susanne V. Schmidt, Anette Christ, Axel Imhof, Karsten Hiller & Eicke Latz: Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase; Immunity; DOI: 10.1016/j.immuni.2019.11.009
