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News Ulas 10.2019
During tumor development, macrophages (brown), the scavengers of the immune system, migrate into the diseased tissue (cancer cells: blue) without destroying it.
© Karin E. de Visser / the Netherlands Cancer Institute

Publication

New method identifies aggressive breast cancer

Aggressive forms of breast cancer often manipulate the immune response in their favor. This manipulation is revealed in humans by the same immunological "signature" as in mice. This is shown by a study carried out by scientists from the University of Bonn and memebers of the Cluster of Excellence ImmunoSensation together with Dutch colleagues. Their method makes it possible to obtain an indication of the prognosis of the disease using patients' tumor tissue. The results are published in the journal "Cell Reports".


Publication

Sander Tuit, Camilla Salvagno, Theodore S. Kapellos, Cheei-Sing Hau, Lea Seep, Marie Oestreich, Kathrin Klee, Karin E. de Visser, Thomas Ulas und Joachim L. Schultze: Transcriptional signature derived from murine tumor-associated macrophages correlates with poor outcome in breast cancer patients. Cell Reports; DOI: 10.1016/j.celrep.2019.09.067

Contact

Dr. Thomas Ulas

Head of the Bioinformatics Working Group

LIMES-Institute

University of Bonn

Tel. +49-228-7362722

E-mail: t.ulas@uni-bonn.de

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Pressefoto

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Decoding the Effects of Obesity

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Image 1: Malaria is not transmitted directly from person to person. Infection requires the bite of a female Anopheles mosquito carrying the malaria parasite. Image 2: Prof. Dr. Achim Hörauf, Director of the Institute of Medical Microbiology, Immunology and Parasitology at Bonn University Hospital (UKB), is an established expert in tropical diseases, among other fields.

Publication

As Temperatures Fall, so does the Risk of Malaria Transmission

—The good news comes with autumn: As temperatures fall, the risk of further malaria transmission in Germany also decreases significantly. However, the current cases reported in the vicinity of Frankfurt Airport show that, in very rare cases, malaria can occur in Germany even without previous travel abroad. In such cases, early diagnosis is crucial.
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New Findings on Information Processing in the Brain: - Examples of Dendritic Shaft Constrictions (DSCs) imaged used high resolution microscopy techniques, expansion microscopy (left), STED (middle) and electron microscopy (right). Arrowheads indicate the position of DSCs.

Publication

New Findings on Information Processing in the Brain

—Neurons receive thousands of signals via tree-like extensions called dendrites. Until now, these dendrites were thought to be relatively smooth cables that conduct electrical signals to the cell body. Using various advanced microscopy techniques, an international research team has identified tiny, previously overlooked constrictions along the dendrites. The study results have now been published in the journal Science Advances.
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