Skip to main content
News Icon

News categories: Publication

New Study published in Nature Methods

Without fat, nothing works in the body: These substances serve as energy suppliers and important building blocks - including for the envelopes of living cells. Numerous diseases are related to disorders in the fat metabolism, such as obesity or cancer. Prof. Christoph Thiele from the LIMES Institute at the University of Bonn and member of the Cluster of Excellence ImmunoSensation and others are now demonstrating how the fat metabolism can be monitored down to the individual liver cell of a mouse with the greatest sensitivity. This opens up several possibilities, such as minimizing the side effects of new drugs on the fat metabolism. The scientists now present their study in the journal "Nature Methods".


Publication

Christoph Thiele, Klaus Wunderling, Philipp Leyendecker: Multiplexed and single cell tracing of lipid metabolism, Nature Methods, DOI: 10.1038/s41592-019-0593-6


Contact

Prof. Dr. Christoph Thiele

University of BonnLife & Medical Sciences Institute (LIMES)

Tel. +49-228-7362818

E-mail: cthiele@uni-bonn.de

Related news

Kato research group

News categories: Publication

Ominous false alarm in the kidney

Bonn researchers have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction. In cooperation with Nanyang Technological University Singapore and the University Hospital Würzburg, among others, the study provides an explanation for how a point mutation in the immune receptor RIG-I transforms the body's defense system into a self-destructive force and causes severe organ-specific autoimmune diseases. The results have now been published in the journal Science Immunology.
View entry
News Icon

News categories: Publication

Unique immune signatures to distinguish MOGAD from MS

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare autoimmune condition in which the body’s immune system mistakenly attacks the protective myelin sheath of nerve fibers in the central nervous system. Although MOGAD induces symptoms similar to multiple sclerosis (MS), its underlying biology appears to be fundamentally different. Understanding these distinctions is crucial for developing effective, disease-specific treatments. A new international study now sheds light on these immune differences.
View entry
Collage Boztug Kalinichenko Huemer 1200px

News categories: Publication

How immune cells deliver their deadly cargo

Precision is crucial for immune cells: natural killer (NK) cells and T cells eliminate infected or transformed cells by releasing targeted, highly toxic particles. A new study from the CeMM (Research Center for Molecular Medicine of the Austrian Academy of Sciences), the St. Anna Children’s Cancer Research Institute, the Medical University of Vienna, the Medical University of Graz, the University Hospital Bonn (UKB) and the University of Bonn offers deeper insight into how these so-called cytotoxic granules are released.
View entry

Back to the news overview