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Operation Method published in Lancet

Cluster Member Prof. Nickenig and an international team of physicians published a recent study about the minimal invasive treatment of tricuspid regurgitation in the Journal 'Lancet'.

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Georg Nickenig, Marcel Weber, Philipp Lurz, Ralph Stephan von Bardeleben, Marta Sitges, Paul Sorajja, et al.: Transcatheter edge-to-edge repair for reduction of tricuspid regurgitation: 6-month outcomes of the TRILUMINATE single-arm study“, The Lancet, Internet: https://doi.org/10.1016/S0140-6736(19)32600-5

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New insights into the human immune defense against poxviruses

An international research team involving Bonn scientist has made an important contribution to understanding the human immune response to poxviruses: The scientists were able to show for the first time that different human cell types recognize poxviruses via different sensors in order to trigger inflammatory responses. At the same time, the team developed the world's first nanobodies that can specifically block the DNA sensor AIM2 – a tool that opens up new possibilities for inflammation and infection research. The paper has now been published in The EMBO Journal.
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Multiple Sclerosis: Potential biomarker linked to progression and brain inflammation identified

Better ways to detect ongoing brain damage in multiple sclerosis (MS) are urgently needed. An international team of scientists, including ImmunoSensation³ member Prof. Anne-Katrin Pröbstel, has identified a molecular circuit that drives brain injury in MS. In a mouse model, blocking the enzyme Bruton's tyrosine kinase prevented harmful clustering of immune cell and brain tissue demage. Patient data revealed the same immune signaling pattern, suggesting strong translational potential for diagnosis. The study was recently published in Nature Immunology.
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Instructions for building antibodies decoded

MOG Antibody-associated Disease (MOGAD) is a rare autoimmune disease of the central nervous system. The blood of patients contains antibodies against myelin oligodendrocyte glycoprotein (MOG), a protein in the myelin layer that surrounds the neurons in the brain. It is believed that these antibodies contribute to the destruction of this protective layer in the brain. Researchers at the University Hospital Bonn (UKB) and the Universities of Basel and Bonn, in collaboration with an international team, have now deciphered the construction plan of the anti-MOG antibodies.
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