—Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition.
Experts from Charité - Universitätsmedizin Berlin, the University of Bonn, the German Center for Neurodegenerative Diseases (DZNE), the Helmholtz Centre for Infection Research (HZI) and the German Center for Infection Research (DZIF), along with colleagues from a nationwide research network, present these findings in "Cell"
—A new study by the University of Bonn and research institutions in Australia and Switzerland shows the strategies that tumor cells use to avoid being attacked by the imune system.The method developed for this work contributes to a better understanding of the "arms race" between immune defense and disease. The results could help to improve modern therapeutic approaches and were published in 'Immunity'.
—All of our cluster member were invited to collect bootle caps, which have have a certain amount of recyclable materials which can be reused. Similar to gold this resource will be recycled and the earnings will be donated to the FÖRDERKREIS BONN E.V..For more than 35 years, the Förderkreis Bonn e.V. has been at the side of youngpatients of the oncology ward of the University Children’s Hospital Bonn.
Funding success for international Research Training Group
—Launched in 2016, the international Research Training Group of the Universities of Bonn and Melbourne will now continue to receive funding until 2025.
Possible SARS-CoV-2 mass testing with new technology
—Prof. Dr. Jonathan Schmid-Burgk heads the new working group for "Functional Immunogenomics" at the Institute for Clinical Chemistry and Clinical Pharmacology at the University Hospital Bonn. As part of the newly established professorship and management position, the 34-year-old genome researcher is investigating the complex interplay between genes and our immune system. With the help of robotics and artificial intelligence (AI), he is developing new techniques for protein analysis in living human cells with programmable gene scissors.
A new tool to study signaling with the help of nanobodies
—A new study of the groups from Dagmar Wachten and Florian I. Schmidt from the Institute of Innate Immunity shows the capability of combining two different techniques for studying unknown processes. The results were published in the Journal eLife.
—Receptor makes mice strong and slim
Study by the University of Bonn identifies molecule that regulates two side effects of aging
Increasing abdominal girth and shrinking muscles are two common side effects of aging. Researchers at the University of Bonn from the Cluster of Excellence ImmunoSensation have discovered a receptor in mice that regulates both effects. Experiments with human cell cultures suggest that the corresponding signaling pathways might also exist in humans. The study, which also involved researchers from Spain, Finland, Belgium, Denmark and the USA, has now been…
—Study by the Universities of Bonn and Nijmegen explains how BCG vaccination reduces susceptibility to infections
A tuberculosis vaccine developed 100 years ago also makes vaccinated persons less susceptible to other infections. While this effect has been recognized for a long time, it is not known what causes it. Together with colleagues from Australia and Denmark, researchers from Radboud university medical center the universities of Nijmegen and Bonn have now presented a possible answer to this question.
—Hairlessness, skin changes, a strong hypersensitivity to light: these are the symptoms of the so-called IFAP syndrome. Scientists from the universities of Beijing, Hamburg and Bonn have now identified a genetic defect that triggers the rare disorder. The results have been published in the "American Journal of Human Genetics".
