Liver cells and western diet - regulating inflammation
—A high fat Western-style diet leads to hepatic steatosis that can progress to liver cancer. Christoph Thiele (LIMES Institute) from the Cluster of Excellence ImmunoSensation and his colleagues used click chemistry-based metabolic tracing and microscopy, to study the interaction between Kupffer cells and hepatocytes ex vivo. The mechanism that leads to the development of steatosis upon nutritional overload is complex and only partially understood. Their study was recently published in the Journal of Cells and could show that inflammatory signals from liver cells…
—A new wiki/ intranet for the Cluster of Excellence ImmunoSensation is now available for our member:
https://confluence.team.uni-bonn.de/x/n4hWAQ
Thereby we use Confluence form the University of Bonn, where some Uni institutions (like the HRZ or Human Resources Development) with their areas can already be found.
In our new wiki / intranet information about our funding opportunities; Software and Hardware within the Cluster or important documentes for e.g. travel expenses can be found.
Access to Confluence is available to all employees with an Uni-ID.The access to the area for the cluster…
—A new consortium COVIMMUNE under the direction of Prof. Eicke Latz, speaker of the cluster of Excellence ImmunoSensation2 is being funded with around 2 Million Euros by the Federal Ministry of Education and Research (BMBF). The project "Understanding divergent host reactions to SARS-CoV-2 infections by precision immunology" (COVIMMUNE) brings together clinical researchers at the University Hospital Bonn who are involved in COVID-19 patient care with basic scientists with immunological expertise from the University of Bonn.
—Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition.
Experts from Charité - Universitätsmedizin Berlin, the University of Bonn, the German Center for Neurodegenerative Diseases (DZNE), the Helmholtz Centre for Infection Research (HZI) and the German Center for Infection Research (DZIF), along with colleagues from a nationwide research network, present these findings in "Cell"
—A new study by the University of Bonn and research institutions in Australia and Switzerland shows the strategies that tumor cells use to avoid being attacked by the imune system.The method developed for this work contributes to a better understanding of the "arms race" between immune defense and disease. The results could help to improve modern therapeutic approaches and were published in 'Immunity'.
—All of our cluster member were invited to collect bootle caps, which have have a certain amount of recyclable materials which can be reused. Similar to gold this resource will be recycled and the earnings will be donated to the FÖRDERKREIS BONN E.V..For more than 35 years, the Förderkreis Bonn e.V. has been at the side of youngpatients of the oncology ward of the University Children’s Hospital Bonn.
Funding success for international Research Training Group
—Launched in 2016, the international Research Training Group of the Universities of Bonn and Melbourne will now continue to receive funding until 2025.
Possible SARS-CoV-2 mass testing with new technology
—Prof. Dr. Jonathan Schmid-Burgk heads the new working group for "Functional Immunogenomics" at the Institute for Clinical Chemistry and Clinical Pharmacology at the University Hospital Bonn. As part of the newly established professorship and management position, the 34-year-old genome researcher is investigating the complex interplay between genes and our immune system. With the help of robotics and artificial intelligence (AI), he is developing new techniques for protein analysis in living human cells with programmable gene scissors.
A new tool to study signaling with the help of nanobodies
—A new study of the groups from Dagmar Wachten and Florian I. Schmidt from the Institute of Innate Immunity shows the capability of combining two different techniques for studying unknown processes. The results were published in the Journal eLife.
