A new tool to study signaling with the help of nanobodies
—A new study of the groups from Dagmar Wachten and Florian I. Schmidt from the Institute of Innate Immunity shows the capability of combining two different techniques for studying unknown processes. The results were published in the Journal eLife.
—Receptor makes mice strong and slim
Study by the University of Bonn identifies molecule that regulates two side effects of aging
Increasing abdominal girth and shrinking muscles are two common side effects of aging. Researchers at the University of Bonn from the Cluster of Excellence ImmunoSensation have discovered a receptor in mice that regulates both effects. Experiments with human cell cultures suggest that the corresponding signaling pathways might also exist in humans. The study, which also involved researchers from Spain, Finland, Belgium, Denmark and the USA, has now been…
—Study by the Universities of Bonn and Nijmegen explains how BCG vaccination reduces susceptibility to infections
A tuberculosis vaccine developed 100 years ago also makes vaccinated persons less susceptible to other infections. While this effect has been recognized for a long time, it is not known what causes it. Together with colleagues from Australia and Denmark, researchers from Radboud university medical center the universities of Nijmegen and Bonn have now presented a possible answer to this question.
—Hairlessness, skin changes, a strong hypersensitivity to light: these are the symptoms of the so-called IFAP syndrome. Scientists from the universities of Beijing, Hamburg and Bonn have now identified a genetic defect that triggers the rare disorder. The results have been published in the "American Journal of Human Genetics".
—Scientists from the Cluster of Excellence ImmunoSensation and the Institute of Science and Technology Austria published their recent findings about microtubules controling migrating cells in the Journal of Cell Biology. Cells need to navigate throughout the body. How they find their right way and how they adapt their body size to moving into the right direction is poorly understood. Here, scientists demonstrate that spatially distinct microtubule dynamics regulate amoeboid cell migration by locally promoting the retraction of protrusions.
—Clotting cells are also an important regulator of inflammation, reveals study by the University of Bonn
Platelets not only play a key role in blood clotting, but can also significantly intensify inflammatory processes. This is shown by a new study carried out by scientists from the Cluster of Excellence ImmunoSensation together with colleagues from Sao Paulo (Brazil). In the medium term, the results could open up new ways to treat autoimmune diseases.
—Prof. Joachim L. Schultze from the LIMES Institute Bonn resigned in his position as speaker and member of the executive board of the Cluster of Excellence.
—The district of Heinsberg in the German state of North Rhine-Westphalia is considered a hot spot for the novel Coronavirus SARS-CoV-2. Following a carnival celebration, the district became one of the first areas in Germany where the pathogen spread and infected large quantities of people. As part of the study, a research team led by Prof. Dr. Hendrik Streeck and Prof. Dr. Gunther Hartmann from the University of Bonn and members of the Cluster of Excellence ImmunoSensation carried out a…
—Until now, the immune sensor TLR8 has remained in the shadows of science. A research team led by members of the Cluster of Excellence ImmunoSensation from the University of Bonn has now discovered how this sensor plays an important role in defending human cells against intruders. The enzymes RNaseT2 and RNase2 cut ribonucleic acids (RNAs) of bacteria into small fragments that are as characteristic as a thumbprint.
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