Skip to main content
News Icon

Publication

Study for treatment of lymphatic filariosis in Science Translational Medicine published

Neglected tropical diseases such as Lymphatic filariosis are common in tropical and subtropical areas. Here mostly poor people are affected.
An international consortium with a contribution of scientists from the Cluster of Excellence ImmunoSensation identified a new substance ABBV-4083 in the fight against adult worms, the cause of lymphatic filariosis.
Dr. Marc Hübner and Prof. Hörauf are working in the Institute of Medical Microbiology, Immunology and Parasitology at the University Hospital Bonn.


Publication

Mark J. Taylor, Thomas W. von Geldern, Louise Ford, Marc P. Hübner, Kennan Marsh, Kelly L. Johnston, Hanna T. Sjoberg, Sabine Specht, Nicolas Pionnier, Hayley E. Tyrer, Rachel H. Clare, Darren A. N. Cook, Emma Murphy, Andrew Steven, John Archer, Dominique Bloemker, Franziska Lenz, Marianne Koschel, Alexandra Ehrens, Haelly M. Metuge, Valerinne C. Chunda, Patrick W. Ndongmo Chounna, Abdel J. Njouendou, Fanny F. Fombad, Robert Carr, Howard E. Morton, Ghaith Aljayyoussi, Achim Hoerauf, Samuel Wanji, Dale J. Kempf, Joseph D. Turner, Stephen A. Ward: Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis, Science Translational Medicine, DOI: 10.1126/scitranslmed.aau2086

Related news

Basmanav

Publication

Inflammatory diseases influence the course of hair loss

—Asthma, atopic dermatitis or Hashimoto's thyroiditis as concomitant diseases are risk factors for clinical features associated with a poor prognosis in circular hair loss, also known as alopecia areata (AA). In patients with three atopic diseases, namely atopic dermatitis, asthma and rhinitis, the average age of onset of AA is about ten years earlier than in patients without chronic inflammatory comorbidities. This has now been established by researchers from Bonn in a large cohort study of affected patients. Their results have now been published in the journal "Allergy".
View entry
Showing how the genes relevant to diseases can be identified more easily - (clockwise from top left): Alexander Hoch, Katja Blumenstock, Marius Jentzsch, Caroline Fandrey und Prof. Jonathan Schmid-Burgk.

Publication

Colored nuclei reveal cellular key genes

—The identification of genes involved in diseases is one of the major challenges of biomedical research. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have developed a method that makes their identification much easier and faster: they light up genome sequences in the cell nucleus. In contrast to complex screenings using established methods, the NIS-Seq method can be used to investigate the genetic determinants of almost any biological process in human cells. The study has now been published in Nature Biotechnology.
View entry
News Florian Schmidt 09 2024

Publication

Central mechanism of inflammation decoded

—The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine to form large pores in the cell membrane, which allow the release of inflammatory messengers. As methods for studying these processes in living cells have so far been inadequate, the sequence of oligomerization, pore formation and membrane incorporation has remained unclear until now.
View entry

Back to the news overview