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Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality.

Tuberculosis (Edinburgh, Scotland)

Authors: Valerie A C M Koeken, Ahmad R Ganiem, Sofiati Dian, Rovina Ruslami, Lidya Chaidir, Mihai G Netea, Vinod Kumar, Bachti Alisjahbana, Reinout van Crevel, Arjan van Laarhoven

Inflammation contributes to the pathophysiology and high mortality of tuberculous meningitis. The IL-1β pathway has been implicated in immunopathology and could be a target for host-directed therapy. IL-1β was elevated in the cerebrospinal fluid (CSF) of 225 HIV-uninfected tuberculous meningitis patients in Indonesia compared to controls, but did not predict subsequent mortality, nor did IL-6 or IL-1Ra. Furthermore, genetic loci known to regulate IL1B gene expression did not predict mortality in 443 tuberculous meningitis patients, although two of these loci did predict CSF IL-1β concentrations. Collectively, these data argue against a role for IL-1β targeted host-directed therapy in tuberculous meningitis.

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

PMID: 33202351

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