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Cytotoxin-associated gene-A-seropositivity and polymorphisms influence adverse cardiovascular events.

International journal of cardiology. Heart & vasculature

Authors: Noriaki Tabata, Daisuke Sueta, Yuichiro Arima, Ken Okamoto, Takashi Shono, Shinsuke Hanatani, Seiji Takashio, Kentaro Oniki, Junji Saruwatari, Kenji Sakamoto, Koichi Kaikita, Jan-Malte Sinning, Nikos Werner, Georg Nickenig, Yutaka Sasaki, Toshihiro Fukui, Kenichi Tsujita

AIMS: Although the bacterial virulent factor of cytotoxin-associated gene-A (CagA)-seropositivity and the host genetic factors of polymorphisms have been suggested to influence -related diseases, the underlying mechanisms of the association between infection and acute coronary syndrome (ACS) remain unknown.

METHODS AND RESULTS: Among 341 consecutive ACS patients, the clinical outcomes after ACS included composite cardiovascular events within the 2-year follow-up period.A significantly higher probability of primary outcomes was observed in positive patients than in negative patients. There were no significant differences in the rate of cardiovascular events between positive and negative patients in the absence of an -polymorphism, while there were significant differences in the presence of an -polymorphism. There were significant differences in the rate of cardiovascular events among CagA positive, CagA negative/ positive and CagA negative/ negative patients. Moreover, via immunohistochemical staining, aortic CagA positive cells were confirmed in the vasa vasorum in CagA positive patients, whereas they could not be identified in CagA negative patients.

CONCLUSIONS: The bacterial virulence factor CagA and host genetic polymorphisms influence the incidence of adverse cardiovascular events, possibly through infection of atherosclerotic lesions. University Hospital Medical Information Network (UMIN)-CTR (http://www.umin.ac.jp/ctr/). UMIN000035696.

© 2020 The Authors.

PMID: 32181324

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