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Discovery of Ircinianin Lactones B and C-Two New Cyclic Sesterterpenes from the Marine Sponge .

Marine drugs

Authors: Thomas Majer, Keshab Bhattarai, Jan Straetener, Justus Pohlmann, Patrick Cahill, Markus O Zimmermann, Marc P Hübner, Marcel Kaiser, Johan Svenson, Michael Schindler, Heike Brötz-Oesterhelt, Frank M Boeckler, Harald Gross

Two new ircinianin-type sesterterpenoids, ircinianin lactone B and ircinianin lactone C ( and ), together with five known entities from the ircinianin compound family (, -) were isolated from the marine sponge . Ircinianin lactones B and C ( and ) represent new ircinianin terpenoids with a modified oxidation pattern. Despite their labile nature, the structures could be established using a combination of spectroscopic data, including HRESIMS and 1D/2D NMR techniques, as well as computational chemistry and quantum-mechanical calculations. In a broad screening approach for biological activity, the class-defining compound ircinianin () showed moderate antiprotozoal activity against (IC 25.4 μM) and (IC 16.6 μM).

PMID: 36005535

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