[Gender-specific differences in the development of colorectal cancer in Lynch syndrome patients-A systematic review].

BACKGROUND: Lynch syndrome (LS) is the most frequent hereditary tumor syndrome and is associated with an increased risk of colorectal cancer (CRC). While gene-specific and age-specific differences are considered in patient surveillance, gender-specific risks in the development of CRC have been reported in many studies but are not consistently documented.

OBJECTIVE: This systematic review aims to investigate gender-specific differences in CRC development among LS patients.

MATERIAL AND METHODS: A systematic literature search following PRISMA 2020 guidelines was conducted in the PubMed, Ovid, The Cochrane Library and Web of Science databases. A total of 688 studies were screened, and 41 met the inclusion criteria.

RESULTS: Men have a higher risk of CRC and develop CRC earlier compared to women.

CONCLUSION: These findings indicate gender-specific differences in the risk of CRC among LS patients, although they do not currently justify separate surveillance strategies.

© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

PMID: 39145869