Innate (learned) memory.

With the growing body of evidence, it is now clear that not only adaptive immune cells but also innate immune cells can mount a more rapid and potent non-specific immune response to subsequent exposures. This process is known as trained immunity or innate (learned) immune memory. In this review, we discuss the different immune and non-immune cell types of the central and peripheral immune systems which can develop trained immunity. We highlight the intracellular signaling, metabolic and epigenetic mechanisms underlying the formation of innate immune memory. Finally, we explore the health implications together with the potential therapeutic interventions harnessing trained immunity.

Copyright © 2023. Published by Elsevier Inc.

PMID: 37385546