Prof. Dr. Mihai Netea
Life & Medical Sciences Institute (LIMES)
mnetea@uni-bonn.de View member: Prof. Dr. Mihai Netea
Cell metabolism
In this issue of Cell Metabolism, Du et al. (2019) describe how insulin-like growth factor 2 (IGF-2), a protein with structural similarity to insulin, induces an anti-inflammatory phenotype in maturing macrophages through reprogramming of their mitochondrial metabolism. These anti-inflammatory properties are maintained upon secondary stimulation and alleviate experimental autoimmune encephalomyelitis (EAE) in vivo.
Copyright © 2019 Elsevier Inc. All rights reserved.
PMID: 31167120