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Modular Synthesis of Halogenated Xanthones by a Divergent Coupling Strategy.

The Journal of organic chemistry

Authors: Jonas W Meringdal, Alexander Kilian, Wingkee C Li, Maximilian J B Heinemann, Marvin Rausch, Tanja Schneider, Dirk Menche

A versatile strategy to halogenated xanthones was developed that relies on a modular coupling of vanillin derivatives with a dibromoquinone. Depending on the reaction conditions, either the 6- or the 7-bromo heterocycles may be obtained in a divergent manner. These heterocycles may be readily further elaborated by sequential Sonogashira couplings, and the sequence may be successfully applied to substructures of the antibiotic lysolipin.

PMID: 35776916

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