Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination.

16/05/2022

The Journal of infectious diseases

Authors: Gereon J Rieke, Kathrin van Bremen, Jenny Bischoff, Michael ToVinh, Malte B Monin, Stefan Schlabe, Jan Raabe, Kim M Kaiser, Claudia Finnemann, Alexandru Odainic, Anushka Kudaliyanage, Eicke Latz, Christian P Strassburg, Christoph Boesecke, Susanne V Schmidt, Benjamin Krämer, Jürgen K Rockstroh, Jacob Nattermann

We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.

PMID: 35323975

Participating cluster members

Prof. Dr. Eicke Latz

Institute of Innate Immunity
eicke.latz@uni-bonn.de View member: Prof. Dr. Eicke Latz
Prof. Dr. med. Jacob Nattermann

Medical Clinic I
jacob.nattermann@ukbonn.de View member: Prof. Dr. med. Jacob Nattermann
Prof. Dr. Christian P. Strassburg

Medical Clinic I - General Internal Medicine
cm.med1@ukbonn.de View member: Prof. Dr. Christian P. Strassburg

Participating cluster members

Prof. Dr. Eicke Latz

Prof. Dr. med. Jacob Nattermann

Prof. Dr. Christian P. Strassburg