Prof. Dr. Michael Hölzel
Institute of Experimental Oncology
michael.hoelzel@ukbonn.de View member: Prof. Dr. Michael Hölzel
Immunity
In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.
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PMID: 32937147