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O-LM interneurons: Gatekeepers of pyramidal neuron activity in the hippocampus.

Neuron

Authors: Stefanie Poll, Martin Fuhrmann

A balanced and fine-tuned ratio of neuronal excitation and inhibition is a prerequisite for information processing. In this issue of Neuron, He et al. (2022) reveal a causal link between reduced input to local somatostatin-expressing, MeCP2-negative O-LM interneurons in CA1 and long-term memory impairment in a mouse model of Rett syndrome.

Copyright © 2022 Elsevier Inc. All rights reserved.

PMID: 35588712

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