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featured publications

  • BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.

    The Journal of experimental medicine

    Authors: Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L Greve, Markus W Löffler, Olaf-Oliver Wolz, Nadine A Schilling, Jasmin B Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N R Weber

  • Top publication

    Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.

    Cell

    Authors: Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T Heneka

  • The influence of the gut microbiome on BCG-induced trained immunity.

    Genome biology

    Authors: Martin Stražar, Vera P Mourits, Valerie A C M Koeken, L Charlotte J de Bree, Simone J C F M Moorlag, Leo A B Joosten, Reinout van Crevel, Hera Vlamakis, Mihai G Netea, Ramnik J Xavier

  • Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: A case series.

    Med (New York, N.Y.)

    Authors: Arjan van Laarhoven, Lisa Kurver, Gijs J Overheul, Emma J Kooistra, Wilson F Abdo, Reinout van Crevel, Raphaël Duivenvoorden, Matthijs Kox, Jaap Ten Oever, Jeroen Schouten, Frank L van de Veerdonk, Hans van der Hoeven, Janette Rahamat-Langendoen, Ronald P van Rij, Peter Pickkers, Mihai G Netea

  • Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.

    Cell reports

    Authors: Shanya Jiang, Nicole M Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A Mandell, Stephen D Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P Weick, Gary A Rosenberg, Eicke Latz, Michael T Heneka, Kiran Bhaskar

  • Practicability of a Virtual Consultation to Evaluate the Shoulder Joint.

    Zeitschrift fur Orthopadie und Unfallchirurgie

    Authors: Martin Gathen, Davide Cucchi, Tom Jansen, Hans Goost, Frank Alexander Schildberg, Christof Burger, Dieter Christian Wirtz, Koroush Kabir, Kristian Welle

  • Knowledge transfer to enhance the performance of deep learning models for automated classification of B cell neoplasms.

    Patterns (New York, N.Y.)

    Authors: Nanditha Mallesh, Max Zhao, Lisa Meintker, Alexander Höllein, Franz Elsner, Hannes Lüling, Torsten Haferlach, Wolfgang Kern, Jörg Westermann, Peter Brossart, Stefan W Krause, Peter M Krawitz

  • MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.

    Nature communications

    Authors: Johannes Brägelmann, Carina Lorenz, Sven Borchmann, Kazuya Nishii, Julia Wegner, Lydia Meder, Jenny Ostendorp, David F Ast, Alena Heimsoeth, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Marcel A Dammert, Dennis Plenker, Sebastian Klein, Philipp Lohneis, Jianing Gu, Laura K Godfrey, Jan Forster, Marija Trajkovic-Arsic, Thomas Zillinger, Mareike Haarmann, Alexander Quaas, Stefanie Lennartz, Marcel Schmiel, Joshua D'Rozario, Emily S Thomas, Henry Li, Clemens A Schmitt, Julie George, Roman K Thomas, Silvia von Karstedt, Gunther Hartmann, Reinhard Büttner, Roland T Ullrich, Jens T Siveke, Kadoaki Ohashi, Martin Schlee, Martin L Sos

  • Blastic plasmacytoid dendritic-cell neoplasia: a challenging case report.

    Journal of cancer research and clinical oncology

    Authors: Ruth-Miriam Koerber, Stefanie A E Held, Maria Vonnahme, Georg Feldmann, Joerg Wenzel, Ines Gütgemann, Peter Brossart, Annkristin Heine

  • The use of IV immunoglobulin in the treatment of vaccine-induced immune thrombotic thrombocytopenia.

    Blood

    Authors: Günalp Uzun, Karina Althaus, Anurag Singh, Peter Möller, Ulf Ziemann, Annerose Mengel, Peter Rosenberger, Martina Guthoff, Gabor C Petzold, Jens Müller, Martin Büchsel, Katharina Feil, Hans Henkes, Nils Heyne, Matthias Maschke, Caroline Limpach, Simon Nagel, Ulrich J Sachs, Falko Fend, Tamam Bakchoul