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featured publications

  • SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.

    Nature communications

    Authors: Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T Trussell, Katelyn X Li, Max L Pöhlmann, Sarah Mackert, Thomas M Geiger, Daniel E Heinz, Roy Lardenoije, Nina Dedic, Kenneth M McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C Robinson, Valentin Stein, Eicke Latz, William A Carlezon, Felix Hausch, Mathias V Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J Ressler, Nils C Gassen

  • Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model.

    Cell reports

    Authors: Brendon D Parsons, Daniel Medina-Luna, Michal Scur, Marinella Pinelli, Gayani S Gamage, Rebecca A Chilvers, Yannick Hamon, Ibrahim H I Ahmed, Stéphane Savary, Andrew P Makrigiannis, Nancy E Braverman, Juan F Rodriguez-Alcazar, Eicke Latz, Tobias K Karakach, Francesca Di Cara

  • Cholesterol Crystal Dissolution Rate of Serum Predicts Outcomes in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

    Journal of the American Heart Association

    Authors: Baravan Al-Kassou, Lara Al-Kassou, Thorsten Mahn, Dieter Lütjohann, Jasmin Shamekhi, Nicola Willemsen, Sven Thomas Niepmann, Stephan Baldus, Malte Kelm, Georg Nickenig, Eicke Latz, Sebastian Zimmer

  • UNC93B1 variants underlie TLR7-dependent autoimmunity.

    Science immunology

    Authors: Christine Wolf, Ee Lyn Lim, Mohammad Mokhtari, Barbara Kind, Alexandru Odainic, Eusebia Lara-Villacanas, Sarah Koss, Simon Mages, Katharina Menzel, Kerstin Engel, Gregor Dückers, Benedikt Bernbeck, Dominik T Schneider, Kathrin Siepermann, Tim Niehues, Carl Christoph Goetzke, Pawel Durek, Kirsten Minden, Thomas Dörner, Anna Stittrich, Franziska Szelinski, Gabriela Maria Guerra, Mona Massoud, Markus Bieringer, Carina C de Oliveira Mann, Eduardo Beltrán, Tilmann Kallinich, Mir-Farzin Mashreghi, Susanne V Schmidt, Eicke Latz, Johanna Klughammer, Olivia Majer, Min Ae Lee-Kirsch

  • Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 2: Assessing Inflammasome Activation.

    Methods in molecular biology (Clifton, N.J.)

    Authors: Marta Lovotti, Matthew S J Mangan, Róisín M McManus, Kateryna Shkarina, Matilde B Vasconcelos, Eicke Latz

  • Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation.

    Methods in molecular biology (Clifton, N.J.)

    Authors: Marta Lovotti, Matthew S J Mangan, Róisín M McManus, Kateryna Shkarina, Matilde B Vasconcelos, Eicke Latz

  • Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.

    Journal of immunology (Baltimore, Md. : 1950)

    Authors: Maximilian Nickenig, Matthew S J Mangan, Hye Eun Lee, Konstantinos Symeonidis, Antonia Henne, Romina Kaiser, Eike Geißmar, Hendrikus Garritsen, Zeinab Abdullah, Karsten Hiller, Eicke Latz, Mario A Lauterbach

  • NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing.

    Nature communications

    Authors: Wei Feng, Joanne C Beer, Qinyu Hao, Ishara S Ariyapala, Aparna Sahajan, Andrei Komarov, Katie Cha, Mason Moua, Xiaolei Qiu, Xiaomei Xu, Shweta Iyengar, Thu Yoshimura, Rajini Nagaraj, Li Wang, Ming Yu, Kate Engel, Lucas Zhen, Wen Xue, Chen-Jung Lee, Chan Ho Park, Cheng Peng, Kaiyuan Zhang, Adrian Grzybowski, Johnnie Hahm, Susanne V Schmidt, Alexandru Odainic, Jasper Spitzer, Kasun Buddika, Dwight Kuo, Lei Fang, Bingqing Zhang, Steve Chen, Eicke Latz, Yiyuan Yin, Yuling Luo, Xiao-Jun Ma

  • PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.

    The Journal of clinical investigation

    Authors: Marta Baldrighi, Christian Doreth, Yang Li, Xiaohui Zhao, Emily F Warner, Hannah Chenoweth, Kamal Kishore, Yagnesh Umrania, David-Paul Minde, Sarah Winkler, Xian Yu, Yuning Lu, Alice Knapton, James Harrison, Murray Ch Clarke, Eicke Latz, Guillermo de Cárcer, Marcos Malumbres, Bernhard Ryffel, Clare E Bryant, Jinping Liu, Kathryn S Lilley, Ziad Mallat, Xuan Li

  • TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.

    The Journal of experimental medicine

    Authors: Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, Yoshio Yamauchi, Yumiko Tsukamoto, Takeshi Ichinohe, Etsuko Fujita, Ryosuke Hiranuma, Ryutaro Fukui, Yoichi Furukawa, Toshio Kitamura, Toshiyuki Takai, Arinobu Tojo, Mamitaro Ohtsuki, Umeharu Ohto, Toshiyuki Shimizu, Manabu Ozawa, Nobuaki Yoshida, Toshiaki Isobe, Eicke Latz, Kojiro Mukai, Tomohiko Taguchi, Hiroaki Hemmi, Shizuo Akira, Kensuke Miyake