Publications

The 2000HIV study: Design, multi-omics methods and participant characteristics.

20/12/2022 Frontiers in immunology

Authors: Wilhelm A J W Vos, Albert L Groenendijk, Marc J T Blaauw, Louise E van Eekeren, Adriana Navas, Maartje C P Cleophas, Nadira Vadaq, Vasiliki Matzaraki, Jéssica C Dos Santos, Elise M G Meeder, Janeri Fröberg, Gert Weijers, Yue Zhang, Jingyuan Fu, Rob Ter Horst, Christoph Bock, Rainer Knoll, Anna C Aschenbrenner, Joachim Schultze, Linos Vanderkerckhove, Talent Hwandih, Elizabeth R Wonderlich, Sai V Vemula, Mike van der Kolk, Sterre C P de Vet, Willem L Blok, Kees Brinkman, Casper Rokx, Arnt F A Schellekens, Quirijn de Mast, Leo A B Joosten, Marvin A H Berrevoets, Janneke E Stalenhoef, Annelies Verbon, Jan van Lunzen, Mihai G Netea, Andre J A M van der Ven

Human variation in population-wide gene expression data predicts gene perturbation phenotype.

12/10/2022 iScience

Authors: Lorenzo Bonaguro, Jonas Schulte-Schrepping, Caterina Carraro, Laura L Sun, Benedikt Reiz, Ioanna Gemünd, Adem Saglam, Souad Rahmouni, Michel Georges, Peer Arts, Alexander Hoischen, Leo A B Joosten, Frank L van de Veerdonk, Mihai G Netea, Kristian Händler, Sach Mukherjee, Thomas Ulas, Joachim L Schultze, Anna C Aschenbrenner

A guide to systems-level immunomics.

22/09/2022 Nature immunology

Authors: Lorenzo Bonaguro, Jonas Schulte-Schrepping, Thomas Ulas, Anna C Aschenbrenner, Marc Beyer, Joachim L Schultze

Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state.

31/08/2022 eLife

Authors: Caterina Carraro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Arik Horne, Marie Oestreich, Stefanie Warnat-Herresthal, Tim Helbing, Michele De Franco, Kristian Haendler, Sach Mukherjee, Thomas Ulas, Valentina Gandin, Richard Goettlich, Anna C Aschenbrenner, Joachim L Schultze, Barbara Gatto

Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.

28/07/2022 Frontiers in immunology

Authors: Kevin Baßler, Wataru Fujii, Theodore S Kapellos, Erika Dudkin, Nico Reusch, Ari Horne, Benedikt Reiz, Malte D Luecken, Collins Osei-Sarpong, Stefanie Warnat-Herresthal, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Allon Wagner, Patrick Günther, Carmen Pizarro, Tina Schreiber, Rainer Knoll, Lisa Holsten, Charlotte Kröger, Elena De Domenico, Matthias Becker, Kristian Händler, Christian T Wohnhaas, Florian Baumgartner, Meike Köhler, Heidi Theis, Michael Kraut, Marc H Wadsworth, Travis K Hughes, Humberto J Ferreira, Emily Hinkley, Ines H Kaltheuner, Matthias Geyer, Christoph Thiele, Alex K Shalek, Andreas Feißt, Daniel Thomas, Henning Dickten, Marc Beyer, Patrick Baum, Nir Yosef, Anna C Aschenbrenner, Thomas Ulas, Jan Hasenauer, Fabian J Theis, Dirk Skowasch, Joachim L Schultze

Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19.

17/05/2022 Cell reports. Medicine

Authors: Amit Frishberg, Emma Kooistra, Melanie Nuesch-Germano, Tal Pecht, Neta Milman, Nico Reusch, Stefanie Warnat-Herresthal, Niklas Bruse, Kristian Händler, Heidi Theis, Michael Kraut, Esther van Rijssen, Bram van Cranenbroek, Hans Jpm Koenen, Hidde Heesakkers, Mark van den Boogaard, Marieke Zegers, Peter Pickkers, Matthias Becker, Anna C Aschenbrenner, Thomas Ulas, Fabian J Theis, Shai S Shen-Orr, Joachim L Schultze, Matthijs Kox

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.

28/12/2021 Cell

Authors: Philipp Georg, Rosario Astaburuaga-García, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J Lippert, Tomislav Kostevc, Christiane Gäbel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemünd, Matthias Barone, Pinkus Tober-Lau, Elisa T Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Mülleder, Simran Kaur Aulakh, Sonja Djudjaj, Roman D Bülow, Henrik E Mei, Axel R Schulz, Andreas Thiel, Stefan Hippenstiel, Antoine-Emmanuel Saliba, Roland Eils, Irina Lehmann, Marcus A Mall, Sebastian Stricker, Jobst Röhmel, Victor M Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer, Saskia von Stillfried, Peter Boor, Münevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Müller-Redetzky, Jacob Nattermann, Wolfgang M Kuebler, Christian Meisel, Markus Ralser, Joachim L Schultze, Anna C Aschenbrenner, Charlotte Thibeault, Florian Kurth, Leif E Sander, Nils Blüthgen, Birgit Sawitzki

Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs.

16/12/2021 Nature communications

Authors: Jan Langkabel, Arik Horne, Lorenzo Bonaguro, Lisa Holsten, Tatiana Hesse, Alexej Knaus, Yannick Riedel, Matthias Becker, Kristian Händler, Tarek Elmzzahi, Kevin Bassler, Nico Reusch, Leon Harootoonovtch Yeghiazarian, Tal Pecht, Adem Saglam, Thomas Ulas, Anna C Aschenbrenner, Franziska Kaiser, Caroline Kubaczka, Joachim L Schultze, Hubert Schorle

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

27/11/2021 Cell

Authors: Daniel Wendisch, Oliver Dietrich, Tommaso Mari, Saskia von Stillfried, Ignacio L Ibarra, Mirja Mittermaier, Christin Mache, Robert Lorenz Chua, Rainer Knoll, Sara Timm, Sophia Brumhard, Tobias Krammer, Henrik Zauber, Anna Luisa Hiller, Anna Pascual-Reguant, Ronja Mothes, Roman David Bülow, Jessica Schulze, Alexander M Leipold, Sonja Djudjaj, Florian Erhard, Robert Geffers, Fabian Pott, Julia Kazmierski, Josefine Radke, Panagiotis Pergantis, Kevin Baßler, Claudia Conrad, Anna C Aschenbrenner, Birgit Sawitzki, Markus Landthaler, Emanuel Wyler, David Horst, Stefan Hippenstiel, Andreas Hocke, Frank L Heppner, Alexander Uhrig, Carmen Garcia, Felix Machleidt, Susanne Herold, Sefer Elezkurtaj, Charlotte Thibeault, Martin Witzenrath, Clément Cochain, Norbert Suttorp, Christian Drosten, Christine Goffinet, Florian Kurth, Joachim L Schultze, Helena Radbruch, Matthias Ochs, Roland Eils, Holger Müller-Redetzky, Anja E Hauser, Malte D Luecken, Fabian J Theis, Christian Conrad, Thorsten Wolff, Peter Boor, Matthias Selbach, Antoine-Emmanuel Saliba, Leif Erik Sander

Alveolar macrophage transcriptomic profiling in COPD shows major lipid metabolism changes.

13/09/2021 ERJ open research

Authors: Wataru Fujii, Theodore S Kapellos, Kevin Baßler, Kristian Händler, Lisa Holsten, Rainer Knoll, Stefanie Warnat-Herresthal, Marie Oestreich, Emily R Hinkley, Jan Hasenauer, Carmen Pizarro, Christoph Thiele, Anna C Aschenbrenner, Thomas Ulas, Dirk Skowasch, Joachim L Schultze