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featured publications

  • Double-Stranded RNA Induces Mortality in an MDA5-Mediated Type I Interferonopathy Model.

    Journal of immunology (Baltimore, Md. : 1950)

    Authors: Francine Lianne Emralino, Saya Satoh, Nobuhiro Sakai, Masamichi Takami, Fumihiko Takeuchi, Nan Yan, Frank Rutsch, Takashi Fujita, Hiroki Kato

  • Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.

    Antiviral research

    Authors: Aileen Faist, Sebastian Schloer, Angeles Mecate-Zambrano, Josua Janowski, André Schreiber, Yvonne Boergeling, Beate C G Conrad, Sriram Kumar, Leonie Toebben, Klaus Schughart, Morris Baumgardt, Mirjana Kessler, Katja Hoenzke, Andreas Hocke, Marcel Trautmann, Wolfgang Hartmann, Hiroki Kato, Ursula Rescher, Anmari Christersson, Joachim Kuehn, Alexander Mellmann, Thorsten Wolff, Philip Kuempers, Alexandros Rovas, Rainer Wiewrodt, Karsten Wiebe, Peter Barth, Stephan Ludwig, Linda Brunotte

  • Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.

    The Journal of experimental medicine

    Authors: Tina Schumann, Santiago Costas Ramon, Nadja Schubert, Mohamad Aref Mayo, Melanie Hega, Katharina Isabell Maser, Servi-Remzi Ada, Lukas Sydow, Mona Hajikazemi, Markus Badstübner, Patrick Müller, Yan Ge, Farhad Shakeri, Andreas Buness, Benjamin Rupf, Stefan Lienenklaus, Barbara Utess, Lina Muhandes, Michael Haase, Luise Rupp, Marc Schmitz, Thomas Gramberg, Nicolas Manel, Gunther Hartmann, Thomas Zillinger, Hiroki Kato, Stefan Bauer, Alexander Gerbaulet, Katrin Paeschke, Axel Roers, Rayk Behrendt

  • Nsp16 shields SARS-CoV-2 from efficient MDA5 sensing and IFIT1-mediated restriction.

    EMBO reports

    Authors: Alina Russ, Sabine Wittmann, Yuta Tsukamoto, Alexandra Herrmann, Janina Deutschmann, Justine Lagisquet, Armin Ensser, Hiroki Kato, Thomas Gramberg

  • Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation.

    Heliyon

    Authors: Mariko Kikuchi, Miki Kadena, Haruka Fukamachi, Takashi Takaki, Shohei Matsui, Sumire Hoashi-Takiguchi, Hirobumi Morisaki, Nataša Trtić, Mina Mori, Mie Kurosawa, Momoe Itsumi, Takahiro Funatsu, Atsuo Sakurai, Seikou Shintani, Hiroki Kato, Takashi Fujita, Yasubumi Maruoka, Hirotaka Kuwata

  • Correction: PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis.

    Cell death & disease

    Authors: Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujita

  • Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model.

    Biochemical and biophysical research communications

    Authors: Sumin Lee, Keiji Hirota, Verena Schuette, Takashi Fujita, Hiroki Kato

  • PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis.

    Cell death & disease

    Authors: Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujita

  • Top publication

    Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19.

    Nature

    Authors: Fotios Karagiannis, Konrad Peukert, Laura Surace, Marcel Michla, Fabian Nikolka, Mario Fox, Patricia Weiss, Caroline Feuerborn, Paul Maier, Susanne Schulz, Burcu Al, Benjamin Seeliger, Tobias Welte, Sascha David, Inge Grondman, Aline H de Nooijer, Peter Pickkers, Jan Lukas Kleiner, Marc Moritz Berger, Thorsten Brenner, Christian Putensen, Hiroki Kato, Natalio Garbi, Mihai G Netea, Karsten Hiller, Katarzyna Placek, Christian Bode, Christoph Wilhelm

  • Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases.

    The EMBO journal

    Authors: Valter Bergant, Shintaro Yamada, Vincent Grass, Yuta Tsukamoto, Teresa Lavacca, Karsten Krey, Maria-Teresa Mühlhofer, Sabine Wittmann, Armin Ensser, Alexandra Herrmann, Anja Vom Hemdt, Yuriko Tomita, Shutoku Matsuyama, Takatsugu Hirokawa, Yiqi Huang, Antonio Piras, Constanze A Jakwerth, Madlen Oelsner, Susanne Thieme, Alexander Graf, Stefan Krebs, Helmut Blum, Beate M Kümmerer, Alexey Stukalov, Carsten B Schmidt-Weber, Manabu Igarashi, Thomas Gramberg, Andreas Pichlmair, Hiroki Kato