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featured publications

  • CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates lipogenesis in adipose tissue.

    Frontiers in immunology

    Authors: Michelle Y Jaeckstein, Isabell Schulze, Michael Wolfgang Zajac, Markus Heine, Oliver Mann, Alexander Pfeifer, Joerg Heeren

  • EPAC1 enhances brown fat growth and beige adipogenesis.

    Nature cell biology

    Authors: Laia Reverte-Salisa, Sana Siddig, Staffan Hildebrand, Xi Yao, Jelena Zurkovic, Michelle Y Jaeckstein, Joerg Heeren, Frank Lezoualc'h, Natalie Krahmer, Alexander Pfeifer

  • Inosine: novel activator of brown adipose tissue and energy homeostasis.

    Trends in cell biology

    Authors: Alexander Pfeifer, Mickel Mikhael, Birte Niemann

  • GPCR in Adipose Tissue Function-Focus on Lipolysis.

    Biomedicines

    Authors: Davide Malfacini, Alexander Pfeifer

  • AdipoQ-a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro.

    Molecular biology of the cell

    Authors: Katharina Sieckmann, Nora Winnerling, Mylene Huebecker, Philipp Leyendecker, Dalila Juliana Silva Ribeiro, Thorsten Gnad, Alexander Pfeifer, Dagmar Wachten, Jan N Hansen

  • Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.

    Nature

    Authors: Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E Müller, Anke Tönjes, Christian Schlein, Azin Jafari, Holger K Eltzschig, Thorsten Gnad, Matthias Blüher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer

  • Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity.

    Microbiome

    Authors: Julia Münzker, Nadine Haase, Andreas Till, Robert Sucher, Sven-Bastiaan Haange, Linda Nemetschke, Thorsten Gnad, Elisabeth Jäger, Jiesi Chen, Sjaak J Riede, Rima Chakaroun, Lucas Massier, Peter Kovacs, Mario Ost, Ulrike Rolle-Kampczyk, Nico Jehmlich, Juliane Weiner, John T Heiker, Nora Klöting, Gudrun Seeger, Markus Morawski, Verena Keitel, Alexander Pfeifer, Martin von Bergen, Joerg Heeren, Ute Krügel, Wiebke K Fenske

  • EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.

    Communications biology

    Authors: Francesca Copperi, Inna Schleis, Martin Roumain, Giulio G Muccioli, Stefano Casola, Martin Klingenspor, Alexander Pfeifer, Thorsten Gnad

  • Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling.

    Frontiers in physiology

    Authors: Ellen Thiemann, Gerburg K Schwaerzer, Ioannis Evangelakos, Marceline M Fuh, Michelle Y Jaeckstein, Janina Behrens, Stefan K Nilsson, Manju Kumari, Ludger Scheja, Alexander Pfeifer, Joerg Heeren, Markus Heine

  • PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.

    Communications biology

    Authors: Staffan Hildebrand, Mohamed Ibrahim, Andreas Schlitzer, Lars Maegdefessel, Wilhelm Röll, Alexander Pfeifer