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  • Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

    PLoS neglected tropical diseases

    Authors: Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf

  • Comparison of null models for combination drug therapy reveals Hand model as biochemically most plausible.

    Scientific reports

    Authors: Mark Sinzger, Jakob Vanhoefer, Carolin Loos, Jan Hasenauer

  • Filarial extract of induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE-knockout mice.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Authors: Constanze Kuehn, Miyuki Tauchi, Roman Furtmair, Katharina Urschel, Dorette Raaz-Schrauder, Anna-Lena Neumann, Stefan J Frohberger, Achim Hoerauf, Susanne Regus, Werner Lang, Tolga Atilla Sagban, Florian Matthias Stumpfe, Stephan Achenbach, Marc P Hübner, Barbara Dietel

  • P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.

    Molecular cell

    Authors: Andrii Bugai, Alexandre J C Quaresma, Caroline C Friedel, Tina Lenasi, Robert Düster, Christopher R Sibley, Koh Fujinaga, Petra Kukanja, Thomas Hennig, Melanie Blasius, Matthias Geyer, Jernej Ule, Lars Dölken, Matjaž Barborič

  • Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.

    Journal of medicinal chemistry

    Authors: Robert T Jacobs, Christopher S Lunde, Yvonne R Freund, Vincent Hernandez, Xianfeng Li, Yi Xia, David S Carter, Pamela W Berry, Jason Halladay, Fernando Rock, Rianna Stefanakis, Eric Easom, Jacob J Plattner, Louise Ford, Kelly L Johnston, Darren A N Cook, Rachel Clare, Andrew Cassidy, Laura Myhill, Hayley Tyrer, Joanne Gamble, Ana F Guimaraes, Andrew Steven, Franziska Lenz, Alexandra Ehrens, Stefan J Frohberger, Marianne Koschel, Achim Hoerauf, Marc P Hübner, Case W McNamara, Malina A Bakowski, Joseph D Turner, Mark J Taylor, Stephen A Ward

  • Letter by Sedaghat and Nickenig Regarding Article, "Device-Related Thrombus After Left Atrial Appendage Closure: Incidence, Predictors, and Outcomes".

    Circulation

    Authors: Alexander Sedaghat, Georg Nickenig

  • Correlation-adjusted regression survival scores for high-dimensional variable selection.

    Statistics in medicine

    Authors: Thomas Welchowski, Verena Zuber, Matthias Schmid

  • Multi-omics identify xanthine as a pro-survival metabolite for nematodes with mitochondrial dysfunction.

    The EMBO journal

    Authors: Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera, Daniele Bano

  • Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons.

    Aging cell

    Authors: Pierre Theurey, Niamh M C Connolly, Ilaria Fortunati, Emy Basso, Susette Lauwen, Camilla Ferrante, Catarina Moreira Pinho, Alvin Joselin, Anna Gioran, Daniele Bano, David S Park, Maria Ankarcrona, Paola Pizzo, Jochen H M Prehn

  • Targeted Nanoparticle Delivery of Bifunctional RIG-I Agonists to Pancreatic Cancer.

    Molecular therapy : the journal of the American Society of Gene Therapy

    Authors: Thomas Zillinger, Gunther Hartmann