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featured publications

  • Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome.

    eLife

    Authors: Frank L van de Veerdonk, Mihai G Netea, Marcel van Deuren, Jos Wm van der Meer, Quirijn de Mast, Roger J Brüggemann, Hans van der Hoeven

  • Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure.

    Cell host & microbe

    Authors: Evangelos J Giamarellos-Bourboulis, Mihai G Netea, Nikoletta Rovina, Karolina Akinosoglou, Anastasia Antoniadou, Nikolaos Antonakos, Georgia Damoraki, Theologia Gkavogianni, Maria-Evangelia Adami, Paraskevi Katsaounou, Maria Ntaganou, Magdalini Kyriakopoulou, George Dimopoulos, Ioannis Koutsodimitropoulos, Dimitrios Velissaris, Panagiotis Koufargyris, Athanassios Karageorgos, Konstantina Katrini, Vasileios Lekakis, Mihaela Lupse, Antigone Kotsaki, George Renieris, Danai Theodoulou, Vassiliki Panou, Evangelia Koukaki, Nikolaos Koulouris, Charalambos Gogos, Antonia Koutsoukou

  • The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan.

    Cell reports

    Authors: Samuel T Keating, Laszlo Groh, Charlotte D C C van der Heijden, Hanah Rodriguez, Jéssica C Dos Santos, Stephanie Fanucchi, Jun Okabe, Harikrishnan Kaipananickal, Jelmer H van Puffelen, Leonie Helder, Marlies P Noz, Vasiliki Matzaraki, Yang Li, L Charlotte J de Bree, Valerie A C M Koeken, Simone J C F M Moorlag, Vera P Mourits, Jorge Domínguez-Andrés, Marije Oosting, Elianne P Bulthuis, Werner J H Koopman, Musa Mhlanga, Assam El-Osta, Leo A B Joosten, Mihai G Netea, Niels P Riksen

  • Involvement of Lactate and Pyruvate in the Anti-Inflammatory Effects Exerted by Voluntary Activation of the Sympathetic Nervous System.

    Metabolites

    Authors: Jelle Zwaag, Rob Ter Horst, Ivana Blaženović, Daniel Stoessel, Jacqueline Ratter, Josephine M Worseck, Nicolas Schauer, Rinke Stienstra, Mihai G Netea, Dieter Jahn, Peter Pickkers, Matthijs Kox

  • Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo.

    Circulation research

    Authors: Charlotte D C C van der Heijden, Laszlo Groh, Samuel T Keating, Charlotte Kaffa, Marlies P Noz, Simone Kersten, Antonius E van Herwaarden, Alexander Hoischen, Leo A B Joosten, Henri J L M Timmers, Mihai G Netea, Niels P Riksen

  • New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia.

    PLoS pathogens

    Authors: Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V Ferreira, Laszlo A Groh, Mirian Domenech, Fernando González-Camacho, Niels P Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G Netea

  • NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium.

    Scientific reports

    Authors: Jose Manuel Sánchez-Maldonado, Manuel Martínez-Bueno, Helena Canhão, Rob Ter Horst, Sonia Muñoz-Peña, Ana Moñiz-Díez, Ana Rodríguez-Ramos, Alejandro Escudero, Signe B Sorensen, Merete L Hetland, Miguel A Ferrer, Bente Glintborg, Ileana Filipescu, Eva Pérez-Pampin, Pablo Conesa-Zamora, Antonio García, Alfons den Broeder, Salvatore De Vita, Svend Erik Hove Jacobsen, Eduardo Collantes, Luca Quartuccio, Mihai G Netea, Yang Li, João E Fonseca, Manuel Jurado, Miguel Ángel López-Nevot, Marieke J H Coenen, Vibeke Andersen, Rafael Cáliz, Juan Sainz

  • Defining trained immunity and its role in health and disease.

    Nature reviews. Immunology

    Authors: Mihai G Netea, Jorge Domínguez-Andrés, Luis B Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A B Joosten, Jos W M van der Meer, Musa M Mhlanga, Willem J M Mulder, Niels P Riksen, Andreas Schlitzer, Joachim L Schultze, Christine Stabell Benn, Joseph C Sun, Ramnik J Xavier, Eicke Latz

  • Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.

    Annals of the rheumatic diseases

    Authors: Viola Klück, Rosanne C van Deuren, Giulio Cavalli, Amara Shaukat, Peer Arts, Maartje C Cleophas, Tania O Crișan, Anne-Kathrin Tausche, Philip Riches, Nicola Dalbeth, Lisa K Stamp, Jennie Harré Hindmarsh, Tim L Th A Jansen, Matthijs Janssen, Marloes Steehouwer, Stefan Lelieveld, Maartje van de Vorst, Christian Gilissen, Lorenzo Dagna, Frank L Van de Veerdonk, Elan Z Eisenmesser, SooHyun Kim, Tony R Merriman, Alexander Hoischen, Mihai G Netea, Charles A Dinarello, Leo Ab Joosten

  • Biomarkers of inflammation and the etiology of sepsis.

    Biochemical Society transactions

    Authors: Inge Grondman, Andrei Pirvu, Anca Riza, Mihai Ioana, Mihai G Netea