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featured publications

  • Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation.

    Methods in molecular biology (Clifton, N.J.)

    Authors: Marta Lovotti, Matthew S J Mangan, Róisín M McManus, Kateryna Shkarina, Matilde B Vasconcelos, Eicke Latz

  • Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.

    Journal of immunology (Baltimore, Md. : 1950)

    Authors: Maximilian Nickenig, Matthew S J Mangan, Hye Eun Lee, Konstantinos Symeonidis, Antonia Henne, Romina Kaiser, Eike Geißmar, Hendrikus Garritsen, Zeinab Abdullah, Karsten Hiller, Eicke Latz, Mario A Lauterbach

  • NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing.

    Nature communications

    Authors: Wei Feng, Joanne C Beer, Qinyu Hao, Ishara S Ariyapala, Aparna Sahajan, Andrei Komarov, Katie Cha, Mason Moua, Xiaolei Qiu, Xiaomei Xu, Shweta Iyengar, Thu Yoshimura, Rajini Nagaraj, Li Wang, Ming Yu, Kate Engel, Lucas Zhen, Wen Xue, Chen-Jung Lee, Chan Ho Park, Cheng Peng, Kaiyuan Zhang, Adrian Grzybowski, Johnnie Hahm, Susanne V Schmidt, Alexandru Odainic, Jasper Spitzer, Kasun Buddika, Dwight Kuo, Lei Fang, Bingqing Zhang, Steve Chen, Eicke Latz, Yiyuan Yin, Yuling Luo, Xiao-Jun Ma

  • PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.

    The Journal of clinical investigation

    Authors: Marta Baldrighi, Christian Doreth, Yang Li, Xiaohui Zhao, Emily F Warner, Hannah Chenoweth, Kamal Kishore, Yagnesh Umrania, David-Paul Minde, Sarah Winkler, Xian Yu, Yuning Lu, Alice Knapton, James Harrison, Murray Ch Clarke, Eicke Latz, Guillermo de Cárcer, Marcos Malumbres, Bernhard Ryffel, Clare E Bryant, Jinping Liu, Kathryn S Lilley, Ziad Mallat, Xuan Li

  • TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.

    The Journal of experimental medicine

    Authors: Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, Yoshio Yamauchi, Yumiko Tsukamoto, Takeshi Ichinohe, Etsuko Fujita, Ryosuke Hiranuma, Ryutaro Fukui, Yoichi Furukawa, Toshio Kitamura, Toshiyuki Takai, Arinobu Tojo, Mamitaro Ohtsuki, Umeharu Ohto, Toshiyuki Shimizu, Manabu Ozawa, Nobuaki Yoshida, Toshiaki Isobe, Eicke Latz, Kojiro Mukai, Tomohiko Taguchi, Hiroaki Hemmi, Shizuo Akira, Kensuke Miyake

  • CD4 T cell calibration of antigen-presenting cells optimizes antiviral CD8 T cell immunity.

    Nature immunology

    Authors: Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H O Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V L Oates, Linden J Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S Gabriel, Wolfgang Kastenmüller, Christian Kurts, Sarah L Londrigan, Axel Kallies, Katherine Kedzierska, Paul J Hertzog, Eicke Latz, Yu-Chen E Chen, Kristen J Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E Sander, Birgit Sawitzki, Joachim L Schultze, Susanne V Schmidt, Sammy Bedoui

  • Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode .

    Vaccines

    Authors: Johanna F Scheunemann, Frederic Risch, Julia J Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe, Eicke Latz, Christoph Coch, Gunther Hartmann, Beatrix Schumak, Achim Hoerauf, Marc P Hübner

  • NULISA: a novel proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing.

    bioRxiv : the preprint server for biology

    Authors: Wei Feng, Joanne Beer, Qinyu Hao, Ishara S Ariyapala, Aparna Sahajan, Andrei Komarov, Katie Cha, Mason Moua, Xiaolei Qiu, Xiaomei Xu, Shweta Iyengar, Thu Yoshimura, Rajini Nagaraj, Li Wang, Ming Yu, Kate Engel, Lucas Zhen, Wen Xue, Chen-Jung Lee, Chan Ho Park, Cheng Peng, Kaiyuan Zhang, Adrian Grzybowski, Johnnie Hahm, Susanne V Schmidt, Alexandru Odainic, Jasper Spitzer, Kasun Buddika, Dwight Kuo, Lei Fang, Bingqing Zhang, Steve Chen, Eicke Latz, Yiyuan Yin, Yuling Luo, Xiao-Jun Ma

  • Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation.

    Nature immunology

    Authors: Danping Zheng, Gayatree Mohapatra, Lara Kern, Yiming He, Merav D Shmueli, Rafael Valdés-Mas, Aleksandra A Kolodziejczyk, Tomasz Próchnicki, Matilde B Vasconcelos, Lena Schorr, Franziska Hertel, Ye Seul Lee, Miguel Camacho Rufino, Emmanuelle Ceddaha, Sandy Shimshy, Ryan James Hodgetts, Mally Dori-Bachash, Christian Kleimeyer, Kim Goldenberg, Melina Heinemann, Noa Stettner, Alon Harmelin, Hagit Shapiro, Jens Puschhof, Minhu Chen, Richard A Flavell, Eicke Latz, Yifat Merbl, Suhaib K Abdeen, Eran Elinav

  • Top publication

    Mitochondrial damage activates the NLRP10 inflammasome.

    Nature immunology

    Authors: Tomasz Próchnicki, Matilde B Vasconcelos, Kim S Robinson, Matthew S J Mangan, Dennis De Graaf, Kateryna Shkarina, Marta Lovotti, Lena Standke, Romina Kaiser, Rainer Stahl, Fraser G Duthie, Maximilian Rothe, Kateryna Antonova, Lea-Marie Jenster, Zhi Heng Lau, Sarah Rösing, Nora Mirza, Clarissa Gottschild, Dagmar Wachten, Claudia Günther, Thomas A Kufer, Florian I Schmidt, Franklin L Zhong, Eicke Latz