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Publications

featured publications

  • The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoter.

    Scientific reports

    Authors: Wilaiporn Saikruang, Lena Ang Yan Ping, Hiroto Abe, Dacquin M Kasumba, Hiroki Kato, Takashi Fujita

  • RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection.

    Molecular therapy. Nucleic acids

    Authors: Samira Marx, Beate M Kümmerer, Christian Grützner, Hiroki Kato, Martin Schlee, Marcel Renn, Eva Bartok, Gunther Hartmann

  • Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis.

    Journal of autoimmunity

    Authors: Taisuke Ohto, Ahmed Abu Tayeh, Ryuta Nishikomori, Hiroto Abe, Kyota Hashimoto, Shiro Baba, Anahi-Paula Arias-Loza, Nobumasa Soda, Saya Satoh, Masashi Matsuda, Yusuke Iizuka, Takashi Kondo, Haruhiko Koseki, Nan Yan, Takahiro Higuchi, Takashi Fujita, Hiroki Kato

  • The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome.

    Viruses

    Authors: Jumana Khalil, Hiroki Kato, Takashi Fujita

  • Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton-Merten syndrome variant.

    International immunology

    Authors: Ahmed Abu Tayeh, Masahide Funabiki, Shota Shimizu, Saya Satoh, Lee Sumin, Yoichiro Iwakura, Hiroki Kato, Takashi Fujita

  • Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5.

    International immunology

    Authors: Hideo Onizawa, Hiroki Kato, Hiroyuki Kimura, Tomoo Kudo, Nobumasa Soda, Shota Shimizu, Masahide Funabiki, Yusuke Yagi, Yuji Nakamoto, Josef Priller, Ryuta Nishikomori, Toshio Heike, Nan Yan, Tohru Tsujimura, Tsuneyo Mimori, Takashi Fujita

  • Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

    Science (New York, N.Y.)

    Authors: Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M Kümmerer, Florian N Gohr, Lea-Marie Jenster, Lisa D J Schiffelers, Yonas M Tesfamariam, Miki Uchima, Jennifer D Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H Christensen, Caroline I Fandrey, Sabine Normann, Jan M P Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A Wilson, Matthias Geyer, Kerstin U Ludwig, B Martin Hällberg, Nicholas C Wu, Florian I Schmidt

  • The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF-B.

    Molecular and cellular biology

    Authors: Jumana Khalil, Shintaro Yamada, Yuta Tsukamoto, Hiroto Abe, Masayuki Shimojima, Hiroki Kato, Takashi Fujita

  • Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes.

    Nucleic acids research

    Authors: Ivana Duic, Hisashi Tadakuma, Yoshie Harada, Ryo Yamaue, Katashi Deguchi, Yuki Suzuki, Shige H Yoshimura, Hiroki Kato, Kunio Takeyasu, Takashi Fujita

  • Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner.

    Virology journal

    Authors: Tim Wai Sha, Michaela Weber, Dacquin M Kasumba, Takeshi Noda, Masahiro Nakano, Hiroki Kato, Takashi Fujita